Regulation of the vasomotor activity of lymph microvessels by nitric oxide and prostaglandins

The American Journal of Physiology
R MizunoG Kaley

Abstract

It was shown previously that the presence of endothelium modulates spontaneous vasomotion of small lymphatic vessels. In the present study, we aimed to elucidate the nature of endothelium-derived factors, produced in basal conditions and in response to agonists, that affect the smooth muscle tone of lymph microvessels in vitro. Afferent lymph microvessels were isolated from rat iliac lymph nodes, cannulated with glass micropipettes, and pressurized (6 cmH2O), and changes in their diameter were investigated with video microscopy. In resting conditions, isolated lymph vessels exhibited spontaneous constrictions and dilations. The maximum and minimum diameters (Dmax and Dmin) were 149.8 +/- 2.9 and 85.8 +/- 3.6 microns, respectively. Acetylcholine (ACh, 10(-7) to 10(-5) M) and sodium nitroprusside (SNP, 10(-8) to 10(-6) M) temporarily abolished diameter oscillations, increasing the diameter of lymphatics dose dependently. For example, 10(-5) M ACh and 10(-6) M SNP increased the diameter (Dmax) by 15.2 +/- 2.2 and 25.0 +/- 2.7 microns, respectively. Treatment of vessels with NG-nitro-L-arginine (10(-4) M) significantly reduced the amplitude of diameter oscillations and nearly completely eliminated ACh-induced dilation of lymph micr...Continue Reading

References

Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S MoncadaR M Palmer
Aug 7, 1985·European Journal of Pharmacology·Y Shirasaki, C Su
Jun 1, 1984·British Journal of Pharmacology·J M AllenN G McHale
Sep 24, 1981·Nature·M G Johnston, J L Gordon
Jan 1, 1994·The Japanese Journal of Physiology·T Ohhashi, S Yokoyama
Oct 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Hyslop, G De Nucci
Jan 1, 1993·Physiological Reviews·K Aukland, R K Reed
Dec 5, 1995·Biochemical and Biophysical Research Communications·L V LeakK Richardson
Jun 1, 1996·The Journal of Physiology·P Y von der WeidD F Van Helden
Feb 12, 1998·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·R MizunoG Kaley

❮ Previous
Next ❯

Citations

Apr 14, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·Y ShirasawaT Ohhashi
May 6, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Theresa F WuPierre-Yves von der Weid
Sep 23, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·J Brandon DixonDavid C Zawieja
Jan 6, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Christopher M QuickRandolph H Stewart
Sep 6, 2011·American Journal of Physiology. Heart and Circulatory Physiology·H Glenn BohlenDavid C Zawieja
Jan 17, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tyler S NelsonJ Brandon Dixon
Sep 4, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey A KornutaJ Brandon Dixon
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jerome W BreslinMack H Wu
Mar 31, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Ranjeet M DongaonkarChristopher M Quick
Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Anatoliy A GashevDavid C Zawieja
Mar 28, 2012·The Journal of Physiology·Pierre-Yves von der WeidMohammad S Imtiaz
Mar 13, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Timothy KassisJ Brandon Dixon
Aug 6, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Andrea N TrujilloJerome W Breslin
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R MizunoT Ohhashi
Nov 5, 2004·World Journal of Gastroenterology : WJG·Hua YuBo-Rong Pan
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P S AndrewS Kaufman
Sep 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Erika TothAkos Koller
Aug 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·H Glenn BohlenDave Zawieja
Aug 30, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Tony J AklAnatoliy A Gashev
Dec 17, 2015·World Journal of Gastroenterology : WJG·Germaine D AgollahSunkuk Kwon
May 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kayoko HosakaToshio Ohhashi
Jun 1, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Niklas TeliniusDonna Briggs Boedtkjer
Nov 8, 2001·American Journal of Physiology. Cell Physiology·K NakayaT Ohhashi
Feb 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ilia FerrusiPierre-Yves von der Weid
Jan 1, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryan Mathias, Pierre-Yves von der Weid
Feb 13, 2016·Annual Review of Biomedical Engineering·Timothy P PaderaLance L Munn
Aug 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Akira KousaiToshio Ohhashi
May 3, 2002·The Journal of Physiology·Anatoliy A GashevDavid C Zawieja
Apr 8, 2020·ACS Pharmacology & Translational Science·Lauren F Sestito, Susan N Thomas

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.