Regulation of thyroid hormone-, oestrogen- and androgen-related genes by triiodothyronine in the brain of Silurana tropicalis.

Journal of Neuroendocrinology
P Duarte-Guterman, Vance L Trudeau

Abstract

Amphibian metamorphosis is an excellent example of hormone-dependent control of development. Thyroid hormones (THs) regulate almost all aspects of metamorphosis, including brain development and larval neuroendocrine function. Sex steroids are also important for early brain function, although little is known about interactions between the two hormonal systems. In the present study, we established brain developmental profiles for thyroid hormone receptors (tralpha and trbeta), deiodinases (dio1, dio2 and dio3), aromatase (cyp19) mRNA and activity, oestrogen receptors (eralpha and erbeta), androgen receptor (ar) and 5alpha-reductases (srd5alpha1 and srd5alpha2) mRNA during Silurana (Xenopus) tropicalis metamorphosis. Real-time reverse transcriptase-polymerase chain reaction analyses revealed that all of the genes were expressed in the brain and for most of the genes expression increased during development, with the exception of dio2, srd5alpha1 and srd5alpha2. The ability of premetamorphic tadpoles to respond to exogenous THs was used to investigate the regulation of TH- and sex steroid-related genes in the brain during development. Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted...Continue Reading

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Citations

Jan 8, 2011·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·V S LangloisV L Trudeau
Aug 9, 2012·The Journal of Endocrinology·Aurea OrozcoCarlota García-G
Apr 2, 2014·General and Comparative Endocrinology·Paula Duarte-GutermanVance L Trudeau
Apr 10, 2014·General and Comparative Endocrinology·Diana E K Flood, Valerie S Langlois
Jul 5, 2016·Mechanisms of Development·Sonja Bissegger, Valerie S Langlois
Sep 13, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Cheryl S RosenfeldVance L Trudeau

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BETA
X04025

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BETA
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