Regulation of tissue factor procoagulant activity by post-translational modifications

Thrombosis Research
Elena M EgorinaBjarne Osterud

Abstract

Post-translational modification of amino acid residues is a common way to regulate localization, stability and ultimately the function of the protein. Tissue factor (TF), the major initiator of blood coagulation cascade, receives several post-translational modifications, like glycosylation, phosphorylation, palmitoylation and nitrosylation. Recent studies have demonstrated that these processes play important roles in modulating biological functions of TF. The present review highlights the mechanisms of several common protein post-translational modifications of TF with the special reference on the recent knowledge about their roles in regulation of trafficking, stability as well as procoagulant and signaling functions of TF.

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Citations

Dec 4, 2009·The Journal of Biological Chemistry·Jolanta Krudysz-AmbloSaulius Butenas
May 14, 2011·Circulation Research·A Phillip Owens, Nigel Mackman
Jul 10, 2012·American Journal of Respiratory Cell and Molecular Biology·Malgorzata WygreckaPhilipp Markart
Mar 20, 2012·Thrombosis Research·Romaric Lacroix, Françoise Dignat-George
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Aug 31, 2020·Research and Practice in Thrombosis and Haemostasis·Axel RosellNigel Mackman

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