Regulation of TLR signaling pathways by microRNAs: implications in inflammatory diseases

Central-European Journal of Immunology
Marina Arenas-Padilla, Veronica Mata-Haro

Abstract

The control of the immune response during the development of some diseases is crucial for the maintenance or restoration of homeostasis. Several mechanisms can initiate inflammation, one of which is the activation of toll-like receptors (TLRs), necessary to initiate the immune response to eliminate an infection. However, inappropriate activation can compromise immunological homeostasis, leading to pathologies such as autoimmune diseases, chronic inflammation, and even cancer. Regulatory mechanisms that intervene in the initiation or modulation of inflammation include microRNAs (miRNAs), which have emerged as key post-transcriptional regulators of proteins involved in distinct cellular processes, such as regulation of the immune response. The focus of this review is on the diverse roles of miRNAs in the regulation of TLR-signaling pathways by targeting multiple molecules, including TLRs, the signaling proteins and cytokines induced by TLRs. It will also address the relationships of these molecules with some diseases that involve inflammation such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), cancer, as well as bacterial or viral infections.

Citations

Aug 14, 2019·Current Opinion in Rheumatology·Alexandra LadouceurSasha Bernatsky
Jan 14, 2020·Cell Biology International·Rui ZhaoYang Chen
Oct 28, 2019·Frontiers in Immunology·Lydia J AthertonRalph A Tripp
Aug 30, 2020·International Journal of Molecular Sciences·Kathryn HallyFabrice Cognasse
Nov 19, 2019·Journal of Oncology·Valentin VautrotJessica Gobbo
Oct 10, 2020·Expert Opinion on Therapeutic Targets·Lauren M Mathias, William Stohl
Jan 21, 2021·International Journal of Molecular Sciences·Cristina Vázquez-CarballoJuan Antonio Moreno
Sep 4, 2021·Neurotoxicology· SushmaSrikanta Kumar Rath

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