Regulation of TRAF2 signaling by self-induced degradation.

The Journal of Biological Chemistry
Kevin D BrownGail A Bishop

Abstract

Receptors belonging to the tumor necrosis factor receptor (TNF-R) family utilize cytoplasmic adapter proteins called TNF-R-associated factors (TRAFs) as key elements in their signaling pathways. However, it is not yet clear how individual TRAFs regulate signaling by this large and growing receptor family. Signaling via the TNF-R family member CD40 has recently been shown to result in recruitment of TRAF2 to plasma membrane detergent-resistant microdomains (lipid rafts) as well as to subsequently initiate TRAF2 degradation. As TRAF2 associates with most members of the TNF-R family, we wished to determine how this degradation occurs. We show here that CD40-mediated TRAF2 degradation requires the zinc-binding RING domain of TRAF2 and is preceded by TRAF2 ubiquitination, suggesting that the TRAF2 RING may promote ubiquitination although the RING itself is not a target of ubiquitination. Several approaches show that ubiquitination and proteasomal activity are integral to TRAF2 degradation, and inhibition of this process potentiates CD40 signaling.

References

Apr 1, 1995·Current Opinion in Cell Biology·M Hochstrasser
Jul 1, 1996·Journal of Leukocyte Biology·M LotzH Schwarz
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·H OdaP M Howley
Sep 28, 1999·Molecular Immunology·I F DunnE N Tsitsikov
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·K L LorickA M Weissman
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S V JalukarG A Bishop
Feb 9, 2000·Current Biology : CB·P S Freemont
Feb 12, 2000·European Journal of Immunology·F K Chan, M J Lenardo
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·F Lafont, K Simons
Oct 12, 2001·Immunologic Research·G A Bishop, B S Hostager

❮ Previous
Next ❯

Citations

Mar 22, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine C BankertGail A Bishop
Mar 26, 2003·Cell Death and Differentiation·H WajantP Scheurich
Feb 7, 2008·European Journal of Immunology·Torry A Tucker, Lisa M Schwiebert
Jan 31, 2004·Current Opinion in Allergy and Clinical Immunology·Simona Ferrari, Alessandro Plebani
Jun 20, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gema Pérez-ChacónJuan M Zapata
Aug 23, 2019·Epigenetics & Chromatin·Joanna BrühlKarim Bouazoune
Feb 26, 2004·The Journal of Experimental Medicine·Ping XieGail A Bishop
Mar 23, 2004·Annual Review of Immunology·Yun-Cai Liu
Oct 2, 2004·Nature Reviews. Immunology·Gail A Bishop
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carissa R Moore, Gail A Bishop
Jan 24, 2006·Cell Death and Differentiation·N T GeorgopoulosL K Trejdosiewicz
Aug 12, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·John P GrahamGail A Bishop
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Hector Ardila-OsorioPierre Busson
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah L RowlandBruce S Hostager
Apr 28, 2005·Science's STKE : Signal Transduction Knowledge Environment·Aaron Laine, Ze'ev Ronai
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·David L Vaux, John Silke
Aug 24, 2010·Immunological Reviews·John P GrahamGail A Bishop
Feb 27, 2010·The Journal of Biological Chemistry·Pradeep BistaMatvey E Lukashev
Nov 22, 2011·Bioorganicheskaia khimiia·L V Onoprienko
Aug 19, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nahid AkhtarSalahuddin Ahmed
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sokol A Haxhinasto, Gail A Bishop
Jun 5, 2003·Expert Opinion on Therapeutic Targets·Juan M Zapata
May 12, 2009·Immunological Reviews·Raul ElguetaRandolph J Noelle
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ping XieGail A Bishop
Oct 25, 2011·Immunological Reviews·Joanne M HildebrandGail A Bishop
Oct 25, 2011·Immunological Reviews·Bärbel Schröfelbauer, Alexander Hoffmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.