Regulation of transcription factor activity during cellular aging

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
K WheatonK Riabowol

Abstract

Several lines of evidence suggest that the limited replication potential of normal human cells is due to the presence of an intrinsic genetic programme. This "senescence programme" is believed to reduce the incidence of cancer by limiting the growth of most of the transformed cells arising in vivo, although some cells do escape senescence becoming both immortalized and transformed. Here we review the literature that describes the senescence process in terms of gene expression and the regulation of gene expression by a variety of mechanisms affecting transcription factor activity. We focus on regulation of the c-fos gene through posttranslational modification of the serum response factor (SRF) as an example of altered gene expression during cellular aging.

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Citations

Mar 27, 2001·Journal of Cellular Physiology·K WheatonK Riabowol
Dec 6, 2001·Diabetes Research and Clinical Practice·B P Yu, H Y Chung
Jan 3, 2003·Neurochemistry International·Desanka MilanovićSabera Ruzdijić
Apr 18, 2000·Experimental Gerontology·J GrillariH Katinger
Mar 4, 2000·Free Radical Biology & Medicine·R G Allen, M Tresini
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G D'IppolitoG A Howard
Mar 15, 2012·Ageing Research Reviews·Wengong Wang
Aug 7, 2012·Journal of Integrative Plant Biology·Yi JiangJinsheng Lai
Apr 9, 1999·Journal of Biological Rhythms·M A SloanA Eskin
May 10, 2017·Functional & Integrative Genomics·Wenlan LiZhaodong Meng

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