PMID: 2500979Jun 26, 1989Paper

Regulation of transmembrane ion transport by reaction products of phospholipase A2. II. Effects of arachidonic acid and other fatty acids on mitochondrial Ca2+ transport

Biochimica Et Biophysica Acta
I Rustenbeck, S Lenzen

Abstract

The effects of arachidonic acid and other fatty acids on mitochondrial Ca2+ transport were studied. Cis-unsaturated fatty acids generally strongly inhibited mitochondrial Ca2+ uptake, induced a net Ca2+ efflux, and thereby increased the extramitochondrial Ca2+ concentration, whereas trans-unsaturated fatty acids were ineffective. Saturated fatty acids exhibited slight activity at chain lengths from C(10) to C(14) only. The structure-activity relationship and the inability of some of the effective fatty acids such as palmitoleic and myristoleic acid to be metabolized to eicosanoids suggest that Ca2+ release was induced by the fatty acids themselves and resulted from changes in the mitochondrial membrane bilayer structure. There was a correlation between Ca2+-releasing potency and reduction of mitochondrial membrane potential, which is the main driving force for mitochondrial Ca2+ uptake. There were, however, considerable differences compared with the effects of lysophospholipids on the membrane potential. The mechanism of action of fatty acids may be that of a fluidizing effect on the hydrophobic core of the membrane, thereby modulating the activity of integral membrane proteins of the respiratory chain.

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Citations

Jul 14, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·J F Dwight, B M Hendry
Jul 1, 1995·The Journal of Nutritional Biochemistry·Jason B. DictenbergK C. Hayes
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Nov 16, 2017·The Journal of Clinical Endocrinology and Metabolism·Sabine KahlMichael Roden
Oct 14, 1991·Biochimica Et Biophysica Acta·I RustenbeckS Lenzen
Mar 31, 1992·Biochemical and Biophysical Research Communications·M L AlessioC L Léger

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