Regulation of tumor cell - Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis

Advances in Biological Regulation
Gabor J TigyiSue Chin Lee

Abstract

The lipid mediator lysophosphatidic acid (LPA) in biological fluids is primarily produced by cleavage of lysophospholipids by the lysophospholipase D enzyme Autotaxin (ATX). LPA has been identified and abundantly detected in the culture medium of various cancer cell types, tumor effusates, and ascites fluid of cancer patients. Our current understanding of the physiological role of LPA established its role in fundamental biological responses that include cell proliferation, metabolism, neuronal differentiation, angiogenesis, cell migration, hematopoiesis, inflammation, immunity, wound healing, regulation of cell excitability, and the promotion of cell survival by protecting against apoptotic death. These essential biological responses elicited by LPA are seemingly hijacked by cancer cells in many ways; transcriptional upregulation of ATX leading to increased LPA levels, enhanced expression of multiple LPA GPCR subtypes, and the downregulation of its metabolic breakdown. Recent studies have shown that overexpression of ATX and LPA GPCR can lead to malignant transformation, enhanced proliferation of cancer stem cells, increased invasion and metastasis, reprogramming of the tumor microenvironment and the metastatic niche, and devel...Continue Reading

Citations

Mar 9, 2019·International Journal of Molecular Sciences·Shi-Hui LawLiang-Yin Ke
Oct 30, 2019·Cellular and Molecular Life Sciences : CMLS·Katarzyna WalczakTomasz Plech
Aug 23, 2020·International Journal of Molecular Sciences·David N BrindleyMatthew G K Benesch
Mar 20, 2020·International Journal of Molecular Sciences·Kuan-Hung LinHsinyu Lee
May 14, 2020·Cancers·Sue Chin LeeGábor J Tigyi
Jan 11, 2020·Journal of Biomolecular Structure & Dynamics·Saima S MirZuhaib F Bhat
Feb 12, 2020·Cancers·Matthew G K BeneschDavid N Brindley
Sep 6, 2020·Biomolecules·Xiaoyun Tang, David N Brindley
Nov 1, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zi WangQin Yu
Nov 6, 2020·Neuromolecular Medicine·Eric Birgbauer
Oct 15, 2020·Cancer Science·Naruomi JinnoHiromi Kataoka
Feb 3, 2021·Signal Transduction and Targeted Therapy·Luiz Henrique Medeiros GeraldoFlavia Regina Souza Lima
Apr 20, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Xiaoyun TangDavid N Brindley
Oct 18, 2020·Progress in Lipid Research·Shu Ting TanLong N Nguyen
Dec 4, 2019·Journal of Medicinal Chemistry·Inés González-GilSilvia Ortega-Gutiérrez
May 27, 2021·Experimental Biology and Medicine·Gábor TigyiSue Chin Lee
Aug 28, 2021·Cells·Pravita BalijepalliKathryn E Meier
Sep 17, 2021·Frontiers in Cellular and Infection Microbiology·Feng ZhaoXianjun Wang
Sep 30, 2021·Brain Pathology·Ángela Gento-CaroBernardo Moreno-López
Nov 2, 2021·Frontiers in Oncology·Yang YuHao Chen
Dec 2, 2021·Leukemia & Lymphoma·Yuxiang LiLisheng Wang

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