PMID: 2502579Aug 1, 1989Paper

Regulation of tyrosinase synthesis and its processing in the hair follicular melanocytes of the mouse during eumelanogenesis and phaeomelanogenesis

The Journal of Investigative Dermatology
S A BurchillAnthony J Thody

Abstract

Tyrosinase synthesis and its posttranslational processing was compared in hair follicular melanocytes of C3H-HeAvy mice during eumelanogenesis and phaeomelanogenesis. Tyrosinase activity was increased during eumelanogenesis and this was paralleled by an increase in tyrosinase synthesis, as measured by the incorporation of [35S]methionine. Although tyrosinase activity was lower during phaeomelanogenesis there was no change in tyrosinase synthesis. alpha-Melanocyte stimulating hormone (alpha-MSH) increased tyrosinase activity and its synthesis during eumelanogenesis but not during phaeomelanogenesis. Bromo-adenosine 3,5-cyclic monophosphate sodium salt (8-bromo-cAMP) was similarly effective during eumelanogenesis, but unlike alpha-MSH stimulated tyrosinase synthesis during phaeomelanogenesis. This suggests that during phaeomelanogenesis the melanocytes may fail to express MSH receptors. This cannot account for the lower tyrosinase activity, however, for alpha-MSH acts predominantly at the level of tyrosinase synthesis and this was similar during eumelanin and phaeomelanin production. The reduced tyrosinase activity is, therefore, presumably due to some posttranslational change. Accordingly, less tyrosinase was associated with the...Continue Reading

References

Feb 10, 1978·Biochimica Et Biophysica Acta·V J HearingK J Tomecki
Jan 1, 1975·Archiv Für Dermatologische Forschung·K Miyazaki, N Otaki
Nov 1, 1986·The Journal of Endocrinology·S A Burchill, A J Thody
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Citations

Nov 1, 1992·Pigment Cell Research·A J Thody, S A Burchill
May 31, 1993·Annals of the New York Academy of Sciences·A J ThodyC Todd
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Marina TsatmaliAnthony J Thody
Jan 7, 1999·Pigment Cell Research·A J Thody, A Graham
Jun 6, 2003·The Journal of Investigative Dermatology·Söbia KauserDesmond J Tobin
Jun 12, 2004·The Journal of Investigative Dermatology·Söbia KauserDesmond J Tobin
Jun 1, 1994·The Journal of Investigative Dermatology·A SlominskiS Lukiewicz
Feb 1, 1991·The Journal of Investigative Dermatology·A SlominskiR Costantino
Aug 22, 2009·Clinics in Dermatology·Lijuan Zhang, Timothy J Falla

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