PMID: 12769669May 29, 2003Paper

Regulation of UDP glucuronosyltransferase genes

Current Drug Metabolism
Peter I MackenzieAnna Radominska-Pandya

Abstract

The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. There are marked interindividual differences in the content of UGTs in the liver and other organs. The mechanisms that lead to these differences are unknown but are most likely the result of differential UGT gene expression. Several transcription factors involved in the regulation of UGT genes have been identified. These include factors such as Hepatocyte Nuclear Factor 1, CAAT-Enhancer Binding Protein, Octamer transcription Factor 1 and Pbx2, which appear to control the constitutive levels of UGTs in tissues and organs. In addition, UGT gene expression is also modulated by hormones, drugs and other foreign chemicals through the action of proteins that bind and/or sense the presence of these chemicals. These proteins include the Ah receptor, members of the nuclear receptor superfamily, such as CAR and PXR and transcription factors that respond to stress.

Citations

Nov 8, 2008·Archives of Toxicology·Alexandra BorzaWolfram Föllmann
Mar 16, 2011·Archives of Toxicology·Nobumitsu HaniokaShizuo Narimatsu
Dec 6, 2011·Archives of Pharmacal Research·Young Hee ChoiYoon Gyoon Kim
Mar 19, 2013·The International Journal of Biochemistry & Cell Biology·Andrew RowlandPeter I Mackenzie
Sep 16, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Doug CrumpSean W Kennedy
Mar 5, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Doug CrumpSean W Kennedy
Nov 25, 2003·Gut·C G DietrichR P J Oude Elferink
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·Alison E AitkenEdward T Morgan
Mar 6, 2012·BMC Genomics·Zhen YangXufang Liang
Jan 26, 2010·BMC Molecular Biology·Anne-Sophie BélangerChantal Guillemette
Jan 1, 2009·Breast Cancer Research and Treatment·Chang Sun, Anna Di Rienzo
Jan 29, 2014·European Journal of Drug Metabolism and Pharmacokinetics·Kohei YamamotoNobumitsu Hanioka
Oct 23, 2013·International Journal of Food Sciences and Nutrition·Hidetomo IwanoHiroshi Yokota
Mar 24, 2015·Expert Opinion on Drug Metabolism & Toxicology·Zoe Riches, Abby C Collier
Jan 15, 2010·Drug Metabolism Reviews·Peter I MackenzieDione A Gardner-Stephen
Jan 14, 2010·Drug Metabolism Reviews·Jean-Marie HeydelAnne-Marie Le Bon
Oct 28, 2009·Drug Metabolism Reviews·Chantal GuillemetteVincent Menard
Jul 16, 2008·Expert Opinion on Drug Metabolism & Toxicology·Xiaochao MaFrank J Gonzalez
Mar 7, 2013·Drug Metabolism Reviews·Satya Prakash TripathiAbhay T Sangamwar
Jul 3, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yuuka MiyakeNobumitsu Hanioka
Aug 24, 2010·Advanced Drug Delivery Reviews·Antonia H Tolson, Hongbing Wang
Aug 18, 2009·Insect Biochemistry and Molecular Biology·Assaf MahadavMurad Ghanim
Aug 10, 2007·Aquatic Toxicology·Michael J LeaverStephen G George
Sep 10, 2011·Basic & Clinical Pharmacology & Toxicology·Nobumitsu HaniokaShizuo Narimatsu
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·UNKNOWN MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk
Jun 14, 2005·Chemico-biological Interactions·Anne-Dorthe Bonde LovenBirgitte Andersen
Mar 26, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sanna KaivosaariMikko Koskinen
Jul 3, 2007·Drug Metabolism and Pharmacokinetics·Xin LiAnna Radominska-Pandya
May 13, 2010·Drug Metabolism and Pharmacokinetics·Yuji IshiiHideyuki Yamada
Mar 19, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yuki KokawaNobumitsu Hanioka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.