Regulation of UDP glucuronosyltransferases in the gastrointestinal tract

Toxicology and Applied Pharmacology
Philip A GregoryPeter I Mackenzie

Abstract

The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic effects of lipophilic chemicals in the environment. UGTs such as UGT1A7, UGT1A8, and UGT1A10 are exclusively expressed in gastrointestinal tissues, each with a unique tissue distribution pattern that is subject to interindividual variation. The factors regulating this tissue-specific expression and that contribute to variability are beginning to be elucidated. Studies on the UGT1A7, 1A8, 1A9, and 1A10 gene promoters in Caco-2 cells, an in vitro model of enterocytes of the gastrointestinal tract, have identified the caudal homeodomain transcription factor, Cdx2, as an important regulator of the UGT1A8 and 1A10 gene proximal promoters. This transcription factor is found exclusively in the small intestine and colon: it is absent in the gastric epithelium and the esophagus. Cdx2 regulates the UGT1A8 and 1A10 promoters in cooperation with hepatocyte nuclear factor 1alpha (HNF1alpha). It is noteworthy that UGT1A7 is not expressed in gastrointestinal tissue distal to the gastric mucosa and does not contain a Cdx2 binding site in its proximal promoter. Transcription factors, including Sp1, which differentially b...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C J KuoG R Crabtree
Jan 1, 1995·Critical Reviews in Biochemistry and Molecular Biology·E H Van BeersJ Dekker
Nov 2, 1995·The New England Journal of Medicine·P J BosmaR P Oude Elferink
Feb 1, 1997·DNA and Cell Biology·A J HansenP I Mackenzie
Mar 6, 1997·Nature·K ChawengsaksophakF Beck
Oct 31, 1998·Biochimica Et Biophysica Acta·A Radominska-PandyaJ P Raufman
Dec 31, 1998·Gastroenterology·C P StrassburgR H Tukey
Jun 9, 1999·The Biochemical Journal·G JedlitschkyB Burchell
Aug 2, 2001·The Journal of Biological Chemistry·Y S Dai, B E Markham
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·M G SoarsR J Riley
Apr 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·U Kristina Walle, Thomas Walle

❮ Previous
Next ❯

Citations

Aug 26, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara A WetmoreRussell S Thomas
Jan 26, 2010·BMC Molecular Biology·Anne-Sophie BélangerChantal Guillemette
Oct 11, 2011·Digestive Diseases and Sciences·Hao ChenXiaoxin Chen
Jul 30, 2010·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Petra JancovaEva Anzenbacherova
Feb 3, 2007·Expert Opinion on Drug Metabolism & Toxicology·Mary F Paine, Nicholas H Oberlies
Feb 3, 2007·Expert Opinion on Drug Metabolism & Toxicology·Joseph K Ritter
Mar 24, 2015·Expert Opinion on Drug Metabolism & Toxicology·Zoe Riches, Abby C Collier
Mar 29, 2014·Drug Metabolism Reviews·Ursula Gundert-RemyPeter H Roos
Jan 15, 2010·Drug Metabolism Reviews·Peter I MackenzieDione A Gardner-Stephen
Oct 28, 2009·Drug Metabolism Reviews·Chantal GuillemetteVincent Menard
Aug 12, 2009·Expert Opinion on Drug Metabolism & Toxicology·Yin Cheong WongZhong Zuo
Feb 18, 2015·Drug Metabolism Reviews·Jolantha BeyerleCornelia M Ulrich
Oct 23, 2014·Drug Metabolism Reviews·Dong Gui HuPeter I Mackenzie
Feb 16, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hong XinLing Yang
Nov 23, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J G SlatterR G Ulrich
Dec 25, 2007·Biochemical Pharmacology·Laure PoquetGary Williamson
Jan 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thérèse SergentYves-Jacques Schneider
Feb 3, 2007·Biochemical Pharmacology·Christoph Köhle, Karl Walter Bock
Nov 11, 2010·Journal of Veterinary Pharmacology and Therapeutics·L MatéC Lanusse
Jun 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·G VirkelC Nebbia
Oct 24, 2006·Toxicology and Applied Pharmacology·Thomayant PrueksaritanontThomas A Baillie
Oct 8, 2005·Pharmacology & Therapeutics·Mikihisa TakanoTeruo Murakami
Jun 15, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Vanessa ZancanellaMauro Dacasto
Jun 18, 2015·The British Journal of Nutrition·Naiara Orrego-LagarónElvira Escribano-Ferrer
Oct 22, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Stefanie HesselAlbrecht Seidel
Nov 23, 2006·Developmental Biology·James D McGheeA Gordon Robertson
Mar 12, 2015·Drug Metabolism and Pharmacokinetics·Shingo OdaMiki Nakajima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.