Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness

Biochimica Et Biophysica Acta
Christina McGuireMichael Forgac

Abstract

V-ATPases are ATP-driven proton pumps that function within both intracellular compartments and the plasma membrane in a wide array of normal physiological and pathophysiological processes. V-ATPases are composed of a peripheral V(1) domain that hydrolyzes ATP and an integral V(0) domain that transports protons. Regulated assembly of the V-ATPase represents an important mechanism of regulating V-ATPase activity in response to a number of environmental cues. Our laboratory has demonstrated that glucose-dependent assembly of the V-ATPase complex in yeast is controlled by the Ras/cAMP/PKA pathway. By contrast, increased assembly of the V-ATPase during dendritic cell maturation involves the PI-3 kinase and mTORC1 pathways. Recently, we have shown that amino acids regulate V-ATPase assembly in mammalian cells, possibly as a means to maintain adequate levels of amino acids upon nutrient starvation. V-ATPases have also been implicated in cancer cell survival and invasion. V-ATPases are targeted to different cellular membranes by isoforms of subunit a, with a3 targeting V-ATPases to the plasma membrane of osteoclasts. We have shown that highly invasive human breast cancer cell lines express higher levels of the a3 isoform than poorly in...Continue Reading

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Citations

May 4, 2016·Biochimica Et Biophysica Acta·Paolo Bernardi
Mar 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Thamiya VasanthakumarJohn L Rubinstein
Mar 5, 2019·Frontiers in Physiology·Summer R HayekKarlett J Parra
Aug 5, 2017·Molecular Cancer Therapeutics·Henriette MerkJohanna Pachmayr
Dec 9, 2020·International Journal of Medical Microbiology : IJMM·Liping PengMingchun Li
Nov 11, 2019·Neurobiology of Disease·Zahra AfghahJonathan D Geiger
Dec 20, 2020·Cellular and Molecular Life Sciences : CMLS·Enrico CastroflorioPeter L Oliver
Feb 1, 2020·Trends in Biochemical Sciences·Thamiya Vasanthakumar, John L Rubinstein
Feb 27, 2021·Scientific Reports·Maria De LucaCecilia Bucci
Sep 1, 2021·Leukemia·Sreoshee RafiqMagali Humbert
Oct 16, 2021·Science Advances·Paula Gutiérrez-PérezLuisa Cochella

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