Jun 24, 2017

Regulation of various DNA repair pathways by E3 ubiquitin ligases

Journal of Cancer Research and Therapeutics
Chandramouli Natarajan, Kenichi Takeda

Abstract

DNA repair is the most important mechanism to maintain the normal cellular homeostasis. Owing to its complicated network, series of posttranslation modifications is required for proper function of the DNA repair proteins. One of such important posttranslation modifications is ubiquitination (attachment of ubiquitin). E3 ubiquitin ligases (UBLs) are a group of proteins that transfer ubiquitin from E2 conjugating enzymes to highly specific substrates such as DNA repair proteins. In this review, we have updated the role of different E3 UBL and how it regulates different DNA repair pathways.

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Mentioned in this Paper

Fanconi Anemia
Biochemical Pathway
Cellular Homeostasis
DNA Repair
Enzymes, antithrombotic
Post-Translational Protein Processing
Regulation of Biological Process
Ubiquitin
Base Excision Repair
Ubiquitin Activity

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