Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase.

Blood
Xavier CullereTanya N Mayadas

Abstract

Endothelial cell-cell junctional proteins and cortical actin are of central importance for regulating vascular permeability. Rap1, a member of the Ras family of GTPases, is enriched at endothelial cell-cell contacts and activated by cyclic AMP (cAMP) through a PKA-independent pathway. Activation of a cAMP-inducible guanine-exchange factor for Rap, Epac, results in markedly enhanced basal endothelial barrier function by increasing cortical actin and subsequent redistribution of adherens and tight junctional molecules to cell-cell contacts. Activation of Epac also counteracts thrombin-induced hyperpermeability through down-regulation of Rho GTPase activation, suggesting cross-talk between Rap and Rho GT-Pases. Thus, Epac/Rap activation represents a new pathway for regulating endothelial cell barrier function.

References

Apr 1, 1989·Journal of Cellular Physiology·T J StelznerR F O'Brien
Jul 1, 1996·Canadian Journal of Physiology and Pharmacology·H Lum, A B Malik
Nov 7, 1998·American Journal of Respiratory Cell and Molecular Biology·A D VerinJ G Garcia
Feb 24, 2001·Endothelium : Journal of Endothelial Cell Research·C E PattersonJ G Garcia
May 2, 2001·Nature Reviews. Molecular Cell Biology·J L BosK A Reedquist
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S K ShawF W Luscinskas
Feb 16, 2002·Science·Andrea L Knox, Nicholas H Brown
Aug 7, 2002·Journal of Anatomy·Victor W M van Hinsbergh, Geerten P van Nieuw Amerongen
Jan 28, 2003·Biochemical Society Transactions·J L BosF Zwartkruis
Feb 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jing QiaoHazel Lum
May 16, 2003·Vascular Pharmacology·Beata Wojciak-Stothard, Anne J Ridley
May 16, 2003·Vascular Pharmacology·Sarah Y Yuan
May 16, 2003·Vascular Pharmacology·Geerten P van Nieuw Amerongen, Victor W M van Hinsbergh
Jun 24, 2003·Nature Cell Biology·Marjorie MailletFrank Lezoualc'h
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·V Vouret-CraviariE Van Obberghen-Schilling
Sep 25, 2003·Nature Reviews. Molecular Cell Biology·Johannes L Bos
Dec 6, 2003·Circulation Research·Panos KouklisAsrar B Malik

❮ Previous
Next ❯

Citations

Jan 8, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Sara S RoscioniMartina Schmidt
Apr 9, 2008·Histochemistry and Cell Biology·Y BaumerJ Waschke
Oct 27, 2009·Pflügers Archiv : European journal of physiology·Mélanie MétrichFrank Lezoualc'h
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yuri PersidskyGeorgette D Kanmogne
Aug 6, 2013·Experimental Cell Research·Magdalena Chrzanowska-Wodnicka
Oct 1, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Hiroki OtaHaruyuki Minamitami
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anneke PostJohannes L Bos
Aug 30, 2011·The Journal of Biological Chemistry·Bryan VanSchouwenGiuseppe Melacini
Apr 19, 2012·The Journal of Biological Chemistry·Kathinka W E M van HoorenRuben Bierings
Nov 23, 2006·The Journal of Experimental Medicine·Valeria V OrlovaTriantafyllos Chavakis
Mar 24, 2010·The Journal of Experimental Medicine·Rebecca A StocktonMark H Ginsberg
Jul 27, 2011·The Journal of Experimental Medicine·Michael SchnoorDietmar Vestweber
Jan 4, 2008·Molecular Biology of the Cell·Seema SehrawatTanya N Mayadas
Jun 3, 2011·Molecular Biology of the Cell·Jian J LiuMark H Ginsberg
Jul 19, 2013·Molecular Biology of the Cell·Anna A BirukovaKonstantin G Birukov
Mar 20, 2010·Cardiovascular Research·Volker SpindlerJens Waschke
May 14, 2010·Cardiovascular Research·Walter N DuránFabiola A Sánchez
Oct 16, 2012·Molecular Pharmacology·Muayad AlmahariqXiaodong Cheng
Sep 22, 2010·Molecular and Cellular Biology·Martijn GloerichJohannes L Bos
May 5, 2010·Molecular and Cellular Biology·Oxana M TsygankovaJudy L Meinkoth
Mar 11, 2009·Molecular and Cellular Biology·Bas PonsioenKees Jalink
Dec 31, 2005·Molecular and Cellular Biology·Marlena DuchniewiczFried J T Zwartkruis
Nov 16, 2011·Biochemistry. Biokhimii︠a︡·S V Shirshev
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Martijn Gloerich, Johannes L Bos
Sep 5, 2008·American Journal of Physiology. Cell Physiology·Jing QiaoHazel Lum
Jan 1, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Senthilkumar RajagopalKarnam S Murthy
Oct 2, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Tracy M CheungGeorge A Truskey
Mar 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·R H AdamsonF E Curry
Aug 19, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Fabiola A SánchezWalter N Durán
Mar 17, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qing LuSharon Rounds
Jul 20, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bing ZhuTroy Stevens
Oct 24, 2009·Journal of Applied Physiology·Anna A BirukovaKonstantin G Birukov
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Grazia TammaMaria Svelto
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Fan YangMark J Fisher
Apr 19, 2008·American Journal of Respiratory Cell and Molecular Biology·Steven K HuangMarc Peters-Golden

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