Regulation of vascular endothelial function by procyanidin-rich foods and beverages

Journal of Agricultural and Food Chemistry
Paul W CatonRoger Corder

Abstract

Flavonoid-rich diets are associated with a lower mortality from cardiovascular disease. This has been linked to improvements in endothelial function. However, the specific flavonoids, or biologically active metabolites, conferring these beneficial effects have yet to be fully defined. In this experimental study of the effect of flavonoids on endothelial function cultured endothelial cells have been used as a bioassay with endothelin-1 (ET-1) synthesis being measured an index of the response. Evaluation of the relative effects of extracts of cranberry juice compared to apple, cocoa, red wine, and green tea showed inhibition of ET-1 synthesis was dependent primarily on their oligomeric procyanidin content. Procyanidin-rich extracts of cranberry juice triggered morphological changes in endothelial cells with reorganization of the actin cytoskeleton and increased immunostaining for phosphotyrosine residues. These actions were independent of antioxidant activity. Comparison of the effects of apple procyanidin monomers through heptamer showed a clear structure-activity relationship. Although monomer, dimer, and trimer had little effect on ET-1 synthesis, procyanidin tetramer, pentamer, hexamer, and heptamer produced concentration-dep...Continue Reading

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Citations

Apr 29, 2010·Current Hypertension Reports·Antje R Weseler, Aalt Bast
May 7, 2013·Annual Review of Nutrition·Samantha Ellam, Gary Williamson
May 29, 2015·Nutrients·Athanasios KoutsosJulie A Lovegrove
Nov 24, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mar QuiñonesAmaya Aleixandre
Feb 20, 2015·Journal of Food Science and Technology·Prasad RasaneV S Unnikrishnan
Oct 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yasuyuki FujiiNaomi Osakabe
Jan 11, 2017·Food Science & Nutrition·Daniel B HannonJohn P Vanden Heuvel
Sep 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lorena CiumărneanGabriela Dogaru

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