Regulation of vasopressin synthesis and release by area postrema in rats

Endocrinology
H ArimaYutaka Oiso

Abstract

There is evidence indicating that the area postrema (AP), the most caudal circumventricular organ located on the dorsal surface of the medulla, is involved in several physiological regulations. In this study, we investigated the role of AP in the regulation of arginine vasopressin (AVP) synthesis and release, using rats of which the AP was lesioned 6 weeks previously. The level of plasma AVP in the AP lesioned (APX) group was significantly lower than in the sham operated (Sham) group in the basal state. AVP release induced by either hyperosmolality or hypovolemia was significantly attenuated by APX. To clarify the role of AP in AVP synthesis in the hypothalamus, we examined the AVP gene expression using in situ hybridization. AVP messenger RNA levels in paraventricular (PVN) and supraoptic nuclei (SON) in the APX group were significantly lower than in the Sham group in the basal state. Moreover, the AVP messenger RNA levels in PVN and SON in the APX group were also significantly lower than in the Sham group after water deprivation for 3 days. These results suggest that AVP synthesis and release are tonically stimulated by AP in the basal state and that AVP synthesis and release in stimulated states are also regulated, at least ...Continue Reading

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Citations

Jan 8, 1999·Brain Research·H E GreenbergD A Ruggiero
Jan 13, 2004·Physiological Reviews·José Antunes-RodriguesSamuel M McCann
Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·W HuangE M Stricker
Jun 27, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Michele IovinoVincenzo Triggiani
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·Y YambeY Oiso
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·S KakiyaY Oiso
Jul 17, 1999·The American Journal of Physiology·K S CurtisE M Stricker
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E M StrickerJ C Smith

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