Regulation of vasopressin V1b receptors and stress adaptation

Annals of the New York Academy of Sciences
S VolpiG Aguilera

Abstract

Vasopressin (VP) regulates pituitary corticotroph function by acting upon plasma membrane G-protein receptors of the V1b subtype (V1bR), coupled to calcium-phospholipid signaling. The number of these receptors in the anterior pituitary varies during stress in direct correlation with corticotroph responsiveness, suggesting that the V1bR plays an important role during adaptation of the hypothalamic-pituitary-adrenal (HPA) axis to stress. The molecular regulation of pituitary V1bR involves transcriptional and translational mechanisms. V1bR gene transcription, which is necessary to maintain V1bR mRNA levels, depends on a number of responsive elements in the promoter region, of which the stretch of GA repeats near the transcription start point (GAGA box) is essential. Although transcriptional activation is necessary to maintain V1bR mRNA levels, the lack of correlation between VP binding and V1bR mRNA suggests that V1bR content is mainly regulated at the translational level. Two potential mechanisms by which the 5' untranslated region (5'UTR) of the V1bR mediates negative and positive regulation of V1bR translation were identified. This includes the repressor effect of small open reading frames (ORF) present upstream of the main V1b...Continue Reading

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Citations

Jun 21, 2008·Endocrinology·Courtney J RiceTallie Z Baram
Apr 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Umer SaleemIftikhar J Kullo
Dec 20, 2011·Hormones and Behavior·Erica L Stevenson, Heather K Caldwell
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Jan 23, 2015·The Journal of Endocrinology·S BabicD Jezova
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Apr 7, 2007·Endocrinology·Sivan Subburaju, Greti Aguilera
Dec 3, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dragana KomnenovNoreen F Rossi

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