Regulation of viral recognition signaling by ubiquitin modification

Uirusu
Kei-ichiro Arimoto, Kunitada Shimotohno

Abstract

As a defense mechanism against infection, host cells have evolved sensor molecules which detect pathogen components directly and induce protective responses against the infection. TLRs, well known receptors, recognize a pathogen on the surface of cells or endosome/lysosome. Many pathogens penetrate into cytoplasm, in where non-TLR sensors recognize pathogen components including double-stranded RNA (dsRNA). On the downstream of each sensor, a variety of functional signaling molecules are activated to produce various cytokines upon the microbial invasion to induce host defense responses. Because that cytokines produced to regulate the host defense responses are known to affect cell proliferation also, the level of these molecules are needed to be controlled tightly, which means requisites of negative regulation of the signaling activated by pathogen after the completion of proper immune responses. Recent studies suggest important roles of some ubiquitin systems in this regulation. Here we focus, in particular, ubiquitin conjugation to signaling molecules by virus activation and like to show how ubiquitin signaling plays roles in this regulation by introducing some recent works.

References

Apr 15, 2003·Nature Immunology·Katherine A FitzgeraldTom Maniatis
Apr 27, 2004·Nature Immunology·Tsung-Hsien Chuang, Richard J Ulevitch
Aug 30, 2005·Nature Immunology·Taro KawaiShizuo Akira
Sep 13, 2005·Molecular Cell·Liang-Guo XuHong-Bing Shu
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Jul 25, 2006·Nature Immunology·Masahiro YamamotoShizuo Akira
Apr 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kei-ichiro ArimotoKunitada Shimotohno
Jun 15, 2007·Molecular and Cellular Biology·Derek W AbbottLewis C Cantley
Aug 28, 2007·Molecular Immunology·Kei-Ichiro ArimotoKunitada Shimotohno
Nov 10, 2007·Science·Nobuhiko KayagakiVishva M Dixit
Dec 1, 2007·Science·Subba Rao NallagatlaPhilip C Bevilacqua
Feb 5, 2008·Molecular Cell·Sheng CuiKarl-Peter Hopfner
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Takashi SatohOsamu Takeuchi

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