PMID: 9420099Jan 7, 1998Paper

Regulation of whole blood tumor necrosis factor production upon endotoxin stimulation after severe blunt trauma

The Journal of Trauma
Matthias MajetschakF U Schade

Abstract

Trauma has been recognized to be accompanied by alterations of leukocyte functions such as cytokine release. The regulatory principles involved in these changes are still poorly defined. To further characterize leukocyte function after multiple trauma, endotoxin-stimulated tumor necrosis factor (TNF) production of trauma patients' whole blood and a possible regulatory mechanism were studied. Endotoxin responsiveness in trauma patients (n = 18, Injury Severity Score = 24 +/- 7) was assayed ex vivo using a whole blood model. TNF release and TNFalpha mRNA levels were determined during a 14-day period. Furthermore, the influence of patients' sera on whole blood TNF production was evaluated. The capacity of trauma patients' whole blood to produce TNF was reduced for 2 to 6 days after trauma and was equally evident for both TNF release and TNFalpha mRNA levels. The reduction of TNF coincides with the appearance of an inhibitory activity for TNF production in trauma patients' sera. No correlation was found between the inhibitory activity and soluble TNF receptors, endotoxin-neutralizing molecules, inhibitory cytokines (interleukin 10 and transforming growth factor beta), or prostaglandins. Major trauma leads to the appearance of a cir...Continue Reading

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Citations

Aug 18, 1999·Annals of Surgery·M MajetschakF Stüber
Jan 10, 2002·Critical Care Medicine·Michael A West, Wyrta Heagy
Jun 20, 2002·Critical Care Medicine·Steven G MuehlstedtJorge L Rodriguez
Oct 11, 2011·Critical Care Medicine·Todd A BakerMatthias Majetschak
Sep 26, 2008·The Journal of Trauma·Olav ReikerasAnsgar O Aasen
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Matthias MajetschakMichael Heesen
Aug 24, 2006·Infection and Immunity·Hongyan XiaoDaniel G Remick
Nov 27, 2002·American Journal of Respiratory and Critical Care Medicine·Jean-Marc Cavaillon
Dec 28, 2010·Critical Care : the Official Journal of the Critical Care Forum·Jon Pérez-BárcenaJosé A Bengoechea
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Jun 5, 2004·The Journal of Trauma·Matthias MajetschakKenneth G Proctor
Jan 1, 2010·International Journal of Tryptophan Research : IJTR·Martin PloderDietmar Fuchs
Nov 8, 2003·Intensive Care Medicine·Sascha FlohéChristian Waydhas
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stilla FredeJoachim Fandrey

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