PMID: 8223252Jan 1, 1993

Regulation of wingless transcription in the Drosophila embryo

Development
P W Ingham, A Hidalgo

Abstract

The segment polarity gene wingless (wg) is expressed in a complex pattern during embryogenesis suggesting that it plays multiple roles in the development of the embryo. The best characterized of these is its role in cell pattening in each parasegment, a process that requires the activity of other segment polarity genes including patched (ptc) and hedgehog (hh). Here we present further evidence that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes. We also show that most other aspects of wg expression are independent of this regulatory network.

Related Concepts

Embryo
Genes, Insect
Wg protein, Drosophila
Embryo Loss
Entire Embryo
Drosophila melanogaster Proteins
Transcription, Genetic
Signal Transduction Pathways
Drosophila
Embryonic Development

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