Regulation of Wnt/β-catenin pathway may be related to Regγ in benign epithelial odontogenic lesions

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Hellen Bandeira de Pontes SantosLélia Batista de Souza

Abstract

The aim of this study was to analyze and compare the immunoexpressions of Regγ, Wnt-1, and β-catenin in ameloblastomas, adenomatoid odontogenic tumors (AOTs), and odontogenic keratocysts (OKCs). Thirty solid ameloblastomas, 20 AOTs, and 30 OKCs were selected for analysis of the immunoexpression of Regγ, Wnt-1, and β-catenin. Each case was semiquantitatively evaluated in the epithelial component and in their different cellular compartments (membrane, cytoplasm, and nucleus). Ameloblastomas displayed higher cytoplasmic and nuclear Regγ expression compared with AOTs and OKCs, as well as higher membrane and cytoplasmic Wnt-1 expression (P < .05). β-catenin membrane expression was higher in OKCs compared with ameloblastomas and AOTs (P < .05). Nuclear β-catenin expression was higher in ameloblastomas and AOTs than in OKCs (P < .05). Cytoplasmic and nuclear Regγ expression in AOTs were positively correlated with nuclear β-catenin expression (P < .05). The marked expressions of Regγ, Wnt-1, and β-catenin suggest the participation of these proteins in the pathogenesis of the studied lesions. The greater expressions of Regγ, Wnt-1, and nuclear β-catenin in ameloblastomas may be related to their more aggressive behavior. Pro-tumor effect...Continue Reading

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