Regulation of Wnt signaling by protein-protein interaction and post-translational modifications

Experimental & Molecular Medicine
Akira KikuchiHideki Yamamoto

Abstract

The Wnt signaling pathway is conserved in various species from worms to mammals, and plays important roles in cellular proliferation, differentiation, and migration. Wnt stabilizes cytoplasmic beta-catenin and then the accumulated beta-catenin is translocated into the nucleus, where it activates the transcriptional factor T-cell factor (Tcf)/lymphoid enhancer factor (Lef), and thereby stimulates the expression of genes including c-myc, c-jun, fra-1, and cyclin D1. Tight regulation of this response involves post-translational modifications of the components of the Wnt signaling pathway. Phosphorylation, ubiquitination, and sumoylation have been shown to affect the half-life of beta-catenin and the transcriptional activity of Tcf/Lef. The precise spatio-temporal patterns of these multiple modifications determine the driving force of various cellular responses.

Citations

Mar 19, 2011·Journal of Mammary Gland Biology and Neoplasia·Rosa SerraSarah E Baxley
Oct 24, 2008·Pituitary·Maria Gueorguiev, Ashley B Grossman
Dec 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Victor H BustosLorenzo A Pinna
Oct 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jennifer A KennellKen M Cadigan
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hong ChenOttavio Cremona
Jan 25, 2008·The Journal of Biological Chemistry·Zhengyu Liu, Joel F Habener
Jan 8, 2010·Molecular Biology of the Cell·Alexandra SegrefIain L Johnstone
Dec 2, 2010·Molecular Biology of the Cell·Avital Hay-KorenRina Rosin-Arbesfeld
Jan 30, 2009·Biology of Reproduction·Jennifer A Hernandez GiffordJohn H Nilson
Mar 31, 2011·Molecular Cancer·Bhavatarini VangamudiWael El-Rifai
Oct 27, 2007·Journal of Molecular Signaling·Noriko YokoyamaCraig C Malbon
Apr 30, 2011·Molecular Endocrinology·Xinyu WuPeng Lee
Aug 14, 2009·PloS One·Dong HuWancai Yang
Jun 30, 2009·Experimental & Molecular Medicine·Hwajin JungEek-hoon Jho
Jun 2, 2011·International Journal of Alzheimer's Disease·Calum Sutherland
Apr 10, 2013·International Journal of Medical Sciences·Jie ZhangHaiying Guo
Dec 21, 2013·Current Colorectal Cancer Reports·Shahid Umar
Jun 18, 2015·International Journal of Oncology·Shaojie JiangGang-Ming Zou
Jul 6, 2014·Advanced Drug Delivery Reviews·Daisuke Sakai, Sibylle Grad
Jul 16, 2008·Trends in Microbiology·Silja Wessler, Steffen Backert
Jul 22, 2008·The Journal of Surgical Research·Pei-Shan WangJoseph J Pinzone
Feb 19, 2008·Experimental Cell Research·Tatsuya YoshidaHiroyoshi Ariga
Sep 15, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Ioan Ovidiu Sirbu, Petra Pandur

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