Regulation of zinc transporter 1 expression in dorsal horn of spinal cord after acute spinal cord injury of rats by dietary zinc

Biological Trace Element Research
Ribao SuLi Zhang

Abstract

Zinc concentrations in the dorsal horn of spinal cord are important for wound healing, neurological function, and reproduction. However, the response of the spinal cord to alterations in dietary zinc is unknown in rats after spinal cord injury (SCI). The current study explored cellular zinc levels and zinc transporter 1 (ZnT1) expression in the dorsal horn of spinal cord with different dietary zinc after SCI. A hundred and forty-four male Wistar rats were randomly divided into four groups: sham-operated group (30 mg Zn/kg), zinc-high dietary SCI model group (ZH, 180 mg Zn/kg), zinc-adequate dietary SCI model group (30 mg Zn/kg), and marginal zinc-deficient dietary SCI model group (MZD, 5 mg Zn/kg). To test the hypothesis that dietary zinc may regulate role of ZnT1 expression in dorsal horn after acute SCI, we traced ZnT1 proteins and zinc ions with immunohistochemistry, western blot, and autometallography. Zinc and ZnT1 levels of the dorsal horn in ZH significantly increased after surgery (P < 0.05), reached peak level (P < 0.05) on the seventh day, and subsequently levels of their expression began to decrease. But zinc levels and ZnT1 expression of spinal cord in MZD dietary groups decreased (P < 0.05) in SCI. There was a posi...Continue Reading

References

Jul 1, 1997·The Journal of Bone and Joint Surgery. British Volume·F E SayeghM Madentzidis
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J McMahon, R J Cousins
Aug 23, 2000·The Journal of Biological Chemistry·S J LangmadeG K Andrews
May 2, 2002·The Journal of Comparative Neurology·Israel SeklerWilliam F Silverman
Oct 19, 2002·Nutritional Neuroscience·E Carden YeiserCathy W Levenson
Oct 9, 2003·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Michael W Pfaffl, Wilhelm Windisch
Nov 24, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Gorm DanscherDorete Jensen
Feb 3, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Gorm Danscher, Meredin Stoltenberg
Feb 14, 2006·Journal of Pharmacological Sciences·Youji KitamuraHideo Saji
May 3, 2007·Molecular Biology Reports·Daoxu SunFeng Kong
Jun 16, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Seung Mook JoSang Won Suh
Sep 6, 2007·Molecular Biology Reports·Lian-ying ZhangFeng Kong
Jan 9, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Wolfgang Maret
Mar 28, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoxi WangBing Zhou
Jul 23, 2009·Synapse·Byron K Y Bitanihirwe, Miles G Cunningham
Sep 18, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yang SongEmily Ho
Sep 29, 2009·Neurotoxicity Research·Ana M AdamoPatricia I Oteiza
May 19, 2010·Journal of Pediatric Gastroenterology and Nutrition·Ming-Yu JouBo Lönnerdal
Aug 31, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Carol J LangRichard Ruffin
Jan 8, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Keigo Nishida
Jul 15, 2011·Medical Hypotheses·Yansong WangGang Lv

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.