Regulations of the key mediators in inflammation and atherosclerosis by aspirin in human macrophages.

Lipids in Health and Disease
Li LuYu Jiang

Abstract

Although its role to prevent secondary cardiovascular complications has been well established, how acetyl salicylic acid (ASA, aspirin) regulates certain key molecules in the atherogenesis is still not known. Considering the role of matrix metalloproteinase-9 (MMP-9) to destabilize the atherosclerotic plaques, the roles of the scavenger receptor class BI (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) to promote cholesterol efflux in the foam cells at the plaques, and the role of NF-kappaB in the overall inflammation related to the atherosclerosis, we addressed whether these molecules are all related to a common mechanism that may be regulated by acetyl salicylic acid. We investigated the effect of ASA to regulate the expressions and activities of these molecules in THP-1 macrophages. Our results showed that ASA inhibited MMP-9 mRNA expression, and caused the decrease in the MMP-9 activities from the cell culture supernatants. In addition, it inhibited the nuclear translocation of NF-kappaB p65 subunit, thus the activity of this inflammatory molecule. On the contrary, acetyl salicylic acid induced the expressions of ABCA1 and SR-BI, two molecules known to reduce the progression of atherosclerosis, at both mRNA and prote...Continue Reading

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Citations

Nov 12, 2013·European Journal of Pharmacology·Mirko MagnoneElena Zocchi
Nov 12, 2010·Journal of Inflammation·Christopher M ScullThomas H Fischer
May 7, 2014·Journal of Clinical Laboratory Analysis·Kavita ShaliaVinod K Shah
Nov 11, 2011·Medical Hypotheses·Muzammal HussainMuhammad Hassan Mushtaq
Mar 9, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jikai LiuShuyi Si
Jul 28, 2019·Current Atherosclerosis Reports·Sanjiv Singh, Avtar Singh Gautam
Oct 18, 2014·World Journal of Clinical Cases·Elisabeth UitzMohammed H Moghadasian
Mar 16, 2019·Nuclear Medicine Communications·He ZhangDengfeng Cheng
Sep 27, 2019·Pharmacological Reviews·Dongdong WangAtanas G Atanasov
Dec 30, 2017·Experimental and Therapeutic Medicine·Ping ZhangCheng-Zeng Yao

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Methods Mentioned

BETA
PCR
ELISA
nuclear translocation

Software Mentioned

Quality One
Quantity One

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