Abstract
Although its role to prevent secondary cardiovascular complications has been well established, how acetyl salicylic acid (ASA, aspirin) regulates certain key molecules in the atherogenesis is still not known. Considering the role of matrix metalloproteinase-9 (MMP-9) to destabilize the atherosclerotic plaques, the roles of the scavenger receptor class BI (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) to promote cholesterol efflux in the foam cells at the plaques, and the role of NF-kappaB in the overall inflammation related to the atherosclerosis, we addressed whether these molecules are all related to a common mechanism that may be regulated by acetyl salicylic acid. We investigated the effect of ASA to regulate the expressions and activities of these molecules in THP-1 macrophages. Our results showed that ASA inhibited MMP-9 mRNA expression, and caused the decrease in the MMP-9 activities from the cell culture supernatants. In addition, it inhibited the nuclear translocation of NF-kappaB p65 subunit, thus the activity of this inflammatory molecule. On the contrary, acetyl salicylic acid induced the expressions of ABCA1 and SR-BI, two molecules known to reduce the progression of atherosclerosis, at both mRNA and prote...Continue Reading
References
Jan 17, 1995·Annals of the New York Academy of Sciences·Z S GalisP Libby
May 23, 1998·BMJ : British Medical Journal·M EcclesJ Mason
Mar 2, 1999·Circulation·X P XuP K Shah
Sep 23, 2000·Nature·A J Lusis
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·J G RozicP K Lala
Aug 22, 2001·Circulation·F CipolloneA Mezzetti
Jan 12, 2002·Biochemical and Biophysical Research Communications·Guorong Lin, Karin E Bornfeldt
Jan 12, 2002·BMJ : British Medical Journal·UNKNOWN Antithrombotic Trialists' Collaboration
Jan 16, 2002·Annals of Internal Medicine·Michael HaydenCynthia Mulrow
Mar 16, 2002·Gene Therapy·S YoshimuraT Ogihara
May 25, 2002·Progress in Cardiovascular Diseases·Prediman K Shah
Sep 5, 2002·Circulation·Tillmann CyrusDomenico Praticò
Oct 9, 2002·The Journal of Clinical Investigation·Ira Tabas
Dec 11, 2002·Circulation·Hiroyasu UzuiTripathi B Rajavashisth
Dec 20, 2002·Nature·Peter Libby
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·John F Oram
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Patricia G YanceyGeorge H Rothblat
Aug 21, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·H Bryan BrewerCharles Joyce
Dec 9, 2004·Atherosclerosis·Yao-Zhong KongHui Y Lan
Mar 17, 2005·Cardiovascular Research·Marisa ViñalsJuan Carlos Laguna
Oct 11, 2005·Atherosclerosis·Almudena Gómez-HernándezJesús Egido
Dec 6, 2005·Atherosclerosis·Tillmann CyrusDomenico Praticò
Citations
Nov 12, 2013·European Journal of Pharmacology·Mirko MagnoneElena Zocchi
Nov 12, 2010·Journal of Inflammation·Christopher M ScullThomas H Fischer
Dec 5, 2015·Inflammation·Ronglin JiangLingcong Wang
May 7, 2014·Journal of Clinical Laboratory Analysis·Kavita ShaliaVinod K Shah
Oct 23, 2014·Mucosal Immunology·K M GowdyM B Fessler
Nov 11, 2011·Medical Hypotheses·Muzammal HussainMuhammad Hassan Mushtaq
Mar 31, 2011·Journal of Dental Research·H Y ChungB P Yu
Mar 9, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jikai LiuShuyi Si
May 9, 2012·Journal of Cardiovascular Pharmacology·Sona MitraJawahar L Mehta
Jul 28, 2019·Current Atherosclerosis Reports·Sanjiv Singh, Avtar Singh Gautam
Oct 18, 2014·World Journal of Clinical Cases·Elisabeth UitzMohammed H Moghadasian
Mar 14, 2014·Journal of Cardiovascular Pharmacology·Jinbao ZhangYongling Tong
Mar 16, 2019·Nuclear Medicine Communications·He ZhangDengfeng Cheng
Sep 27, 2019·Pharmacological Reviews·Dongdong WangAtanas G Atanasov
Dec 30, 2017·Experimental and Therapeutic Medicine·Ping ZhangCheng-Zeng Yao