PMID: 24359503Dec 24, 2013Paper

Regulator of calcineurin 1 gene transcription is regulated by nuclear factor-kappaB

Current Alzheimer Research
Lanlan ZhengXiulian Sun

Abstract

Regulator of calcineurin 1 (RCAN1) has been implicated in pathogenesis of neurodegeneration and various cancers. Recently, we showed that RCAN1 expression was elevated in Down Syndrome and Alzheimer's disease and its expression transpose over induced neuronal apoptosis. As NF-κB is an important transcription factor involved in cell survival and RCAN1 played vital roles in cell viability, we examined whether NF-κB regulates RCAN1 gene expression. Our results here showed that the RCAN1 isoform 4 gene transcription can be activated by NF-κB signaling. NF-κB activated RCAN1 isoform 4 gene promoter. Luciferase assay, electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation identified a NF-κB responsive element in the region of -576-554bp of the RCAN1 isoform 4 promoter. Activation of RCAN1 gene expression by NF-κB is independent from the calcineurin-NFAT signaling since the NF-κB responsive element was distinct from the NFAT binding sites that was previously identified in the region of -350-166bp. Indeed, activation of calcineurin-NFAT signaling decreased NF-κB transcriptional activity, while activation of NF-κB elevated NFAT transcriptional activity. RCAN1 isoform 4 gene transcription was repressed by its own p...Continue Reading

Citations

Jun 23, 2020·BioMed Research International·Kaixin QiuYili Wu
Aug 12, 2014·Molecular Brain·Xiaoling DuanWeihong Song
Oct 23, 2015·Cell Death & Disease·C LiuX Sun
Jan 1, 2020·Molecular Brain·Shou YangWeihong Song

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