Regulators of Androgen Action Resource: a one-stop shop for the comprehensive study of androgen receptor action

Database : the Journal of Biological Databases and Curation
Adam D DePriestHannelore V Heemers

Abstract

Androgen receptor (AR) is a ligand-activated transcription factor that is the main target for treatment of non-organ-confined prostate cancer (CaP). Failure of life-prolonging AR-targeting androgen deprivation therapy is due to flexibility in steroidogenic pathways that control intracrine androgen levels and variability in the AR transcriptional output. Androgen biosynthesis enzymes, androgen transporters and AR-associated coregulators are attractive novel CaP treatment targets. These proteins, however, are characterized by multiple transcript variants and isoforms, are subject to genomic alterations, and are differentially expressed among CaPs. Determining their therapeutic potential requires evaluation of extensive, diverse datasets that are dispersed over multiple databases, websites and literature reports. Mining and integrating these datasets are cumbersome, time-consuming tasks and provide only snapshots of relevant information. To overcome this impediment to effective, efficient study of AR and potential drug targets, we developed the Regulators of Androgen Action Resource (RAAR), a non-redundant, curated and user-friendly searchable web interface. RAAR centralizes information on gene function, clinical relevance, and re...Continue Reading

Citations

Jun 2, 2017·Endocrine-related Cancer·Sangeeta KumariHannelore V Heemers
Mar 14, 2018·Cold Spring Harbor Perspectives in Medicine·Margaret M CenteneraWayne D Tilley
Apr 9, 2017·Cold Spring Harbor Perspectives in Medicine·Charles DaiNima Sharifi

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Methods Mentioned

BETA
Chem-Seq

Software Mentioned

Apache
GeneCard
MyISAM
Linux
PHP
cBioPortal
RAAR
MySQL
NURSA

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