Regulatory abnormalities in the marrow of patients with myelodysplastic syndromes.

British Journal of Haematology
S MerchavI Tatarsky

Abstract

Regulation of haemopoiesis in the marrow of patients with myelodysplastic syndromes (MDS) was evaluated by assaying (1) the production of haemopoietic regulators acting upon multipotent and committed progenitors by MDS marrow cells, and (2) the responsiveness of MDS marrow progenitors to stimulation with granulocyte colony-stimulating factor (G-CSF). The levels of multipotent progenitor cell colony-stimulating activity (CFU-GEMMCSA) in 7 d bone marrow-conditioned medium (BMCM) from MDS patients were markedly reduced as compared to controls. MDS BMCM also exhibited reduced levels of burst-promoting activity (BPA) for primitive erythroid (BFU-E) progenitors. Both CFU-GEMMCSA and BPA detected in BMCM were completely neutralized by antibodies directed against interleukin-3. MDS BMCM exhibited markedly reduced levels of murine-active CSA. This activity was partially neutralized by anti-CSF-1 antibodies. Levels of regulators in BMCM of refractory anaemia (RA), sideroblastic anaemia. RA with excess blasts, and chronic myelomonocyte leukaemia were virtually the same. CFU-GEMM and BFU-E growth in MDS marrow (n = 9) was markedly reduced. A 5-fold saturating dose of G-CSF induced an approximately 2-fold increase in CFU-GEMM in four of eig...Continue Reading

References

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Citations

Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·W VerbeekW Hiddemann
Jan 1, 1992·International Journal of Clinical & Laboratory Research·A GanserD Hoelzer
May 1, 1996·Critical Reviews in Oncology/hematology·J F San MiguelM A Sanz
Jun 1, 1993·British Journal of Haematology·G VisaniS Tura
Apr 1, 1992·Journal of the American Geriatrics Society·A Mansouri, D A Lipschitz

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