PMID: 20653170Jul 27, 2010Paper

Regulatory action of charred Gossamer urocteae on the functions of mouse oral fibroblasts

Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan
Jian-ping DaiXiao-kun Zhou

Abstract

To explore the influence of charred Gossamer urocteae (CGU) on the functions of primary cultured mouse oral fibroblasts and reveal its mechanism in wound healing. CGU was extracted with different solvents and ethanol extract (EE), ethyl acetate fraction (EF), n-butanol fraction (BF) and aqueous fraction (AF) were obtained. The effects of different fractions on the proliferation, matrix metalloproteinase-2,9 (MMP-2,9) activities, synthesis of collagen and tissue inhibitor of metalloproteinase 1 (TIMP-1) in the mouse oral fibroblasts were determined by MTT, gelatin zymography, chloramine-T method, and enzyme-linked immunosorbent assay (ELISA) respectively. EE, EF and BF at high concentrations could significantly inhibit proliferation of fibroblasts (P<0.05 or P<0.01), and at low concentrations EF and BF could promote proliferation of fibroblasts, and BF and AF could significantly inhibit collagen synthesis (P<0.05 or P<0.01). EE, EF and AF at high concentrations could significantly increase the MMP-9 activity, and BF and AF could significantly inhibit synthesis of TIMP-1. CGU at high concentrations can inhibit the proliferations of fibroblasts and synthesis of collagen, and in healing of wound, CGU at high concentrations possibly...Continue Reading

References

Jun 10, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·C A Edwards, W D O'Brien
Oct 20, 1998·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·K HehenbergerA Hansson
May 26, 1999·American Journal of Respiratory Cell and Molecular Biology·D F GibbsJ Varani
Feb 9, 2008·The International Journal of Biochemistry & Cell Biology·Ian M ClarkDylan R Edwards

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