Regulatory and Functional Aspects of Indolic Metabolism in Plant Systemic Acquired Resistance

Molecular Plant
Elia StahlJürgen Zeier

Abstract

Tryptophan-derived, indolic metabolites possess diverse functions in Arabidopsis innate immunity to microbial pathogen infection. Here, we investigate the functional role and regulatory characteristics of indolic metabolism in Arabidopsis systemic acquired resistance (SAR) triggered by the bacterial pathogen Pseudomonas syringae. Indolic metabolism is broadly activated in both P. syringae-inoculated and distant, non-inoculated leaves. At inoculation sites, camalexin, indol-3-ylmethylamine (I3A), and indole-3-carboxylic acid (ICA) are the major accumulating compounds. Camalexin accumulation is positively affected by MYB122, and the cytochrome P450 genes CYP81F1 and CYP81F2. Local I3A production, by contrast, occurs via indole glucosinolate breakdown by PEN2- dependent and independent pathways. Moreover, exogenous application of the defense hormone salicylic acid stimulates I3A generation at the expense of its precursor indol-3-ylmethylglucosinolate (I3M), and the SAR regulator pipecolic acid primes plants for enhanced P. syringae-induced activation of distinct branches of indolic metabolism. In uninfected systemic tissue, the metabolic response is more specific and associated with enhanced levels of the indolics I3A, ICA, and in...Continue Reading

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Citations

Jan 4, 2019·The Plant Journal : for Cell and Molecular Biology·Yuhuan MiaoLongfu Zhu
Jul 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Anna KoprivovaStanislav Kopriva
Aug 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Michela SalvatoreAnna Andolfi
Apr 17, 2018·The Plant Journal : for Cell and Molecular Biology·Katrin GrunerJürgen Zeier
Dec 31, 2020·International Journal of Molecular Sciences·Lisa DavidSixue Chen
Sep 13, 2021·The New Phytologist·Esteban AlfonsoPhilippe Reymond
Jun 11, 2021·Molecular Plant-microbe Interactions : MPMI·José S RufiánGitta L Coaker

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