Regulatory B Cells and Mechanisms

International Reviews of Immunology
Héctor Rincón-ArévaloGloria Vásquez

Abstract

Regulatory B cells have gained prominence in their role as modulators of the immune response against tumors, infectious diseases, and autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, among others. The concept of regulatory B cells has been strongly associated with interleukin (IL)-10 production; however, there is growing evidence that supports the existence of other regulatory mechanisms, such as the production of transforming growth factor β (TGF-β), induced cell death of effector T cells, and the induction of CD4(+)CD25(-)Foxp3(+) regulatory T cells. The regulatory function of B cells has been associated with the presence and activation of molecules such as CD40, CD19, CD1d, and BCR. Alterations in signaling by any of these pathways leads to a marked defect in regulatory B cells and to increased clinical symptoms and proinflammatory signs, both in murine models and in autoimmune diseases in humans. B cells mainly exert their regulatory effect through the inhibition of proliferation and production of proinflammatory mediators, such as TNF-α, IFN-γ, and IL-17 by CD4(+) T cells. A better understanding of how regulatory B cells function will offer new perspectives with regar...Continue Reading

References

Apr 1, 1994·European Journal of Immunology·F WillemsM Goldman
Jan 1, 1995·Immunology Today·S Nagata, T Suda
Apr 1, 1996·The Journal of Experimental Medicine·G S GilkesonD S Pisetsky
Jul 1, 1996·The Journal of Experimental Medicine·H GrouxM G Roncarolo
Dec 31, 1997·The Journal of Experimental Medicine·A MizoguchiA K Bhan
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·S P ColganR S Blumberg
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J TianD L Kaufman
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elina ZuñigaAdriana Gruppi
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Veit HornungGunther Hartmann
Sep 24, 2002·Nature Immunology·Simon FillatreauStephen M Anderton
Feb 20, 2003·The Journal of Experimental Medicine·Claudia MauriMarco Londei
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuhito HamaguchiThomas F Tedder
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aurelia LartiguePhilippe Musette
Sep 16, 2006·Nature Reviews. Immunology·Andreas RadbruchFalk Hiepe
Oct 24, 2006·Journal of Neuroimmunology·Abigail C Buenafe, Dennis N Bourdette
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monica K MannBonnie N Dittel
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jamie G EvansClaudia Mauri
Jun 26, 2007·Scandinavian Journal of Immunology·S AmuM Brisslert
Jul 3, 2007·Inflammatory Bowel Diseases·Martin GoetzMarkus F Neurath
Aug 1, 2007·Arthritis and Rheumatism·Shouvik DassPaul Emery
Sep 18, 2007·Science·Marijn van der Neut KolfschotenPaul W H I Parren
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shabbir Hussain, Terry L Delovitch
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vicky LampropoulouSimon Fillatreau
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin N CouperEleanor M Riley
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anurag SinghCraig M Schramm
Jul 26, 2008·Annals of Neurology·Jorge CorrealeGabriela Razzitte
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul A BlairClaudia Mauri
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arumugam PalanichamyJennifer H Anolik
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koichi YanabaThomas F Tedder
Feb 16, 2010·Nature Reviews. Immunology·Margarida Saraiva, Anne O'Garra
Mar 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min YangLiwei Lu
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rei WatanabeManabu Fujimoto
Jul 14, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takashi MatsushitaThomas F Tedder
Jul 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven M LeonardoStephen B Gauld
Dec 1, 2010·Cytokine & Growth Factor Reviews·Robert SabatJens Geginat
Feb 2, 2011·The American Journal of Pathology·Koichi YanabaShinichi Sato

❮ Previous
Next ❯

Citations

Jan 10, 2018·Frontiers in Immunology·Suzanne A B M AartsEsther Lutgens
May 16, 2020·Frontiers in Immunology·Priyanshu SrivastavaSujatha Sunil
Apr 4, 2021·International Journal of Molecular Sciences·Laura BeneckeLaurent Muller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Clinical Reviews in Allergy & Immunology
Dana Ben-Ami ShorYehuda Shoenfeld
International Journal of Hygiene and Environmental Health
Michelle Rocha-PariseMary L S Queiroz
© 2021 Meta ULC. All rights reserved