Regulatory control and the costs and benefits of biochemical noise.

PLoS Computational Biology
Sorin Tănase-Nicola, Pieter Rein ten Wolde

Abstract

Experiments in recent years have vividly demonstrated that gene expression can be highly stochastic. How protein concentration fluctuations affect the growth rate of a population of cells is, however, a wide-open question. We present a mathematical model that makes it possible to quantify the effect of protein concentration fluctuations on the growth rate of a population of genetically identical cells. The model predicts that the population's growth rate depends on how the growth rate of a single cell varies with protein concentration, the variance of the protein concentration fluctuations, and the correlation time of these fluctuations. The model also predicts that when the average concentration of a protein is close to the value that maximizes the growth rate, fluctuations in its concentration always reduce the growth rate. However, when the average protein concentration deviates sufficiently from the optimal level, fluctuations can enhance the growth rate of the population, even when the growth rate of a cell depends linearly on the protein concentration. The model also shows that the ensemble or population average of a quantity, such as the average protein expression level or its variance, is in general not equal to its tim...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M A Savageau
Oct 11, 1992·Nucleic Acids Research·P Kolkhof
Jun 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M A Savageau
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J R SadlerJ L Betz
Aug 22, 1995·Proceedings. Biological Sciences·S Gavrilets, A Hastings
Feb 5, 2000·Nature·M B Elowitz, S Leibler
Dec 7, 2000·Biophysical Journal·P B DetwilerB I Shraiman
Apr 23, 2002·Nature Genetics·Ertugrul M OzbudakAlexander van Oudenaarden
Aug 17, 2002·Science·Michael B ElowitzPeter S Swain
Jan 30, 2004·Nature·Johan Paulsson
May 29, 2004·Genetics·Mukund Thattai, Alexander van Oudenaarden
Jul 20, 2004·Clinical Microbiology Reviews·Marjan W van der Woude, Andreas J Bäumler
Aug 17, 2004·Science·Nathalie Q BalabanStanislas Leibler
Dec 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tatsuo Shibata, Koichi Fujimoto
Feb 3, 2005·Genetics·Edo KussellStanislas Leibler
Mar 11, 2005·Journal of Theoretical Biology·Denise M WolfAdam P Arkin
Mar 11, 2005·Molecular Biology and Evolution·Andreas Wagner
Mar 26, 2005·Science·Nitzan RosenfeldMichael B Elowitz
Mar 26, 2005·Science·Juan M Pedraza, Alexander van Oudenaarden
May 11, 2005·Nature Reviews. Genetics·Mads KaernJames J Collins
Jul 30, 2005·Evolution; International Journal of Organic Evolution·Xu-Sheng Zhang, William G Hill
Aug 9, 2005·Nature Genetics·Attila BecskeiAlexander van Oudenaarden
Sep 24, 2005·Science·Jonathan M Raser, Erin K O'Shea
Feb 3, 2006·Nature·D W AustinM L Simpson
Dec 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·W Gilbert, B Müller-Hill
May 23, 2006·Nature Genetics·Arren Bar-EvenNaama Barkai
Oct 10, 2006·Physical Review Letters·Sorin Tănase-NicolaPieter Rein ten Wolde
Nov 24, 2006·Nature·Alex SigalUri Alon
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Erel Levine, Terence Hwa
Oct 25, 2007·PloS One·Etay ZivChris H Wiggins
Nov 10, 2007·Physical Biology·Tomer KaliskyUri Alon
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ting LuJeff Hasty

❮ Previous
Next ❯

Citations

Oct 15, 2013·Nucleic Acids Research·Marcin TabakaRobert Hołyst
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Michael Y Pavlov, Måns Ehrenberg
May 9, 2012·Annual Review of Cell and Developmental Biology·Peter L Freddolino, Saeed Tavazoie
Jan 3, 2009·Journal of Biological Engineering·Travis S BayerChristina D Smolke
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marco J MorelliRosalind J Allen
Aug 19, 2011·BMC Systems Biology·Frank J PoelwijkSander J Tans
Sep 9, 2011·PLoS Computational Biology·Che-Chi ShuDoraiswami Ramkrishna
Jan 10, 2013·PloS One·Gregor MoenkeKeven Thurley
Aug 17, 2012·Proceedings. Biological Sciences·Hsuan-Chao ChiuDaniel Segrè
Sep 2, 2010·Systems and Synthetic Biology·Daniil ZhuravelMads Kærn
Feb 13, 2016·BMC Biology·Noreen WalkerSander J Tans
Mar 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mikihiro HashimotoYuichi Wakamoto
Jan 19, 2012·Molecular Systems Biology·Hiroyuki Kuwahara, Orkun S Soyer
Mar 23, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Simon de BecoLaura A Johnston
May 18, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Orkun S Soyer, Maureen A O'Malley
Jul 23, 2015·Evolution; International Journal of Organic Evolution·Jeremy Draghi, Michael Whitlock
Apr 14, 2016·Current Biology : CB·Bram CerulusKevin J Verstrepen
Jun 18, 2015·ELife·Luise WolfErik van Nimwegen
Jun 16, 2010·PLoS Computational Biology·Rutger HermsenPieter Rein ten Wolde
May 3, 2013·PloS One·Sarah BoulineauSander J Tans
Nov 5, 2016·Scientific Reports·Elena AgliariAntonio Moro
Mar 9, 2017·Molecular BioSystems·R G BrajeshSupreet Saini
Aug 21, 2018·ELife·Fabien DuveauPatricia J Wittkopp
Oct 6, 2018·PLoS Computational Biology·Istvan T KleijnRutger Hermsen
Mar 24, 2016·PLoS Computational Biology·Andrew MuglerAleksandra M Walczak
Jan 14, 2009·Nature Reviews. Genetics·Darren J Wilkinson
Nov 19, 2009·Molecular Systems Biology·Theodore J Perkins, Peter S Swain
Jan 27, 2016·PLoS Computational Biology·Araks MartirosyanAndrea De Martino
Jul 20, 2019·Nature Communications·Jörn M SchmiedelBen Lehner
Oct 27, 2020·PLoS Computational Biology·Michael Schmutzer, Andreas Wagner
Jun 26, 2013·The Journal of Physical Chemistry. B·Thierry Mora, Aleksandra M Walczak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.