Regulatory control of the Na-Cl co-transporter NCC and its therapeutic potential for hypertension.

Acta Pharmaceutica Sinica. B
Nur Farah Meor AzlanJinwei Zhang

Abstract

Hypertension is the largest risk factor for cardiovascular disease, the leading cause of mortality worldwide. As blood pressure regulation is influenced by multiple physiological systems, hypertension cannot be attributed to a single identifiable etiology. Three decades of research into Mendelian forms of hypertension implicated alterations in the renal tubular sodium handling, particularly the distal convoluted tubule (DCT)-native, thiazide-sensitive Na-Cl cotransporter (NCC). Altered functions of the NCC have shown to have profound effects on blood pressure regulation as illustrated by the over activation and inactivation of the NCC in Gordon's and Gitelman syndromes respectively. Substantial progress has uncovered multiple factors that affect the expression and activity of the NCC. In particular, NCC activity is controlled by phosphorylation/dephosphorylation, and NCC expression is facilitated by glycosylation and negatively regulated by ubiquitination. Studies have even found parvalbumin to be an unexpected regulator of the NCC. In recent years, there have been considerable advances in our understanding of NCC control mechanisms, particularly via the pathway containing the with-no-lysine [K] (WNK) and its downstream target ...Continue Reading

References

Feb 1, 1992·Journal of the American Society of Nephrology : JASN·K S KamelM L Halperin
Dec 1, 1991·Journal of the American Society of Nephrology : JASN·R J BindelsC H van Os
Jul 1, 1996·Kidney International·M D PlotkinS C Hebert
Aug 11, 2001·Science·F H WilsonR P Lifton
Nov 13, 2001·American Journal of Physiology. Renal Physiology·J LoffingB Kaissling
Jun 1, 2002·Journal of the American Society of Nephrology : JASN·Joke C De JongRené J M Bindels
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Robert S HooverSteven C Hebert
Jan 31, 2003·American Journal of Physiology. Renal Physiology·Jens Leipziger
Apr 2, 2003·Hypertension·Pasquale StrazzulloGianvincenzo Barba
Apr 3, 2003·The Journal of Clinical Investigation·Chao-Ling YangDavid H Ellison
Apr 22, 2003·The Journal of Biological Chemistry·Joke C de JongRené J M Bindels
Apr 8, 2004·American Journal of Physiology. Renal Physiology·Ernesto SabathGerardo Gamba
Jun 1, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Mitsunobu Matsubara
Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Johannes LoffingBrigitte Kaissling
Sep 15, 2004·The Journal of Clinical Hypertension·Doemnic A Sica
Nov 27, 2004·American Journal of Nephrology·Gheun-Ho Kim
Aug 20, 2005·American Journal of Hypertension·Anke-Hilse Maitland-van der ZeeEric Boerwinkle
Oct 12, 2005·The Journal of Biological Chemistry·Rama SoundararajanDavid Pearce
Nov 3, 2005·The Journal of Biological Chemistry·Tetsuo MoriguchiHiroshi Shibuya
Aug 5, 2006·The Journal of Biological Chemistry·Diana Pacheco-AlvarezGerardo Gamba
Sep 15, 2006·Journal of the American Society of Nephrology : JASN·Elisa BabiloniaWen-Hui Wang
Mar 3, 2007·Journal of the American Society of Nephrology : JASN·Eva Riveira-MunozUNKNOWN Belgian Network for Study of Gitelman Syndrome
Sep 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hendrica BelgeOlivier Devuyst
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Benjamin KoRobert S Hoover
Dec 18, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miriam Zacchia, Giovambattista Capasso
May 13, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eva Riveira-MunozKarin Dahan
Oct 14, 2008·Nature Chemical Biology·Beth ApselZachary A Knight
Dec 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ying WangYen-Pei C Chang
Apr 30, 2009·The Journal of Biological Chemistry·Arohan R SubramanyaPaul A Welling
Sep 11, 2009·Biochemistry·Yukiko I YagiKoji Sode
Oct 31, 2009·Journal of the American Society of Nephrology : JASN·Bo ZhouHui Cai
Nov 17, 2009·Photochemistry and Photobiology·Spyridon K CharisisMiltiadis K Tsilimbaris
Dec 17, 2009·Behavioural Brain Research·Yang GengEric Delpire

❮ Previous
Next ❯

Citations

Oct 18, 2020·Cells·Nur Farah Meor Azlan, Jinwei Zhang
Jan 31, 2021·International Journal of Molecular Sciences·Sunday Solomon JosiahJinwei Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Biochemical and Biophysical Research Communications
Muhammad Zakir Hossain KhanShinichi Uchida
Annals of Indian Academy of Neurology
Mohit GirotraJeyaraj D Pandian
American Journal of Physiology. Renal Physiology
Benjamin KoRobert S Hoover
© 2021 Meta ULC. All rights reserved