Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human Host

Frontiers in Physiology
Shiek S S J AhmedV Ramakrishnan

Abstract

We dissect the mechanism of SARS-CoV-2 in human lung host from the initial phase of receptor binding to viral replication machinery. Two independent lung protein interactome were constructed to reveal the signaling process on receptor activation and host protein hijacking machinery in the pathogenesis of virus. Further, we test the functional role of the hubs derived from the interactome. Most hubs proteins were differentially regulated on SARS-CoV-2 infection. Also, the proteins in viral replication hubs were related with cardiovascular disease, diabetes and hypertension confirming the vulnerability and severity of infection in the risk individual. Additionally, the hub proteins were closely linked with other viral infection, including MERS and HCoVs which suggest similar infection pattern in SARS-CoV-2. We identified five hubs that interconnect both networks that show the preparation of optimal environment in the host for viral replication process upon receptor attachment. Interestingly, we propose that seven potential miRNAs, targeting the intermediate phase that connects receptor and viral replication process a better choice as a drug for SARS-CoV-2.

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Citations

Apr 4, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rafael MarchiLuciane R Cavalli
Jun 8, 2021·Frontiers in Veterinary Science·Herbert F JelinekHabiba S Alsafar
Jun 23, 2021·Journal of Biomolecular Structure & Dynamics·Amit KumawatJayant K Singh
Jul 28, 2021·Molecular Neurobiology·Shiek S S J AhmedRam Murugesan

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Datasets Mentioned

BETA
GSE147507

Methods Mentioned

BETA
affinity purification
RNA-Seq

Software Mentioned

DESeq
Access
R
MCODE

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