May 11, 2018

Regulatory Divergence in Wound-Responsive Gene Expression between Domesticated and Wild Tomato

The Plant Cell
Ming-Jung LiuShin-Han Shiu

Abstract

The evolution of transcriptional regulatory mechanisms is central to how stress response and tolerance differ between species. However, it remains largely unknown how divergence in cis-regulatory sites and, subsequently, transcription factor (TF) binding specificity contribute to stress-responsive expression divergence, particularly between wild and domesticated species. By profiling wound-responsive gene transcriptomes in wild Solanum pennellii and domesticated S. lycopersicum, we found extensive wound response divergence and identified 493 S. lycopersicum and 278 S. pennellii putative cis-regulatory elements (pCREs) that were predictive of wound-responsive gene expression. Only 24-52% of these wound response pCREs (depending on wound response patterns) were consistently enriched in the putative promoter regions of wound-responsive genes across species. In addition, between these two species, their differences in pCRE site sequences were significantly and positively correlated with differences in wound-responsive gene expression. Furthermore, ∼11-39% of pCREs were specific to only one of the species and likely bound by TFs from different families. These findings indicate substantial regulatory divergence in these two plant spe...Continue Reading

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Mentioned in this Paper

Study
Biological Adaptation to Stress
Transcriptional Regulation
Genes
Transcription, Genetic
Tomatoes
Gene Expression Regulation, Plant
Injury Wounds
Gene Expression
Wild bird

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