Regulatory DNAs and the evolution of human development

Current Opinion in Genetics & Development
James P Noonan

Abstract

Changes in gene regulation have long been thought to underlie biological differences between humans and other primates. Recent advances have facilitated the study of human-specific sequence changes in regulatory DNAs in the context of human development. Comparative genomic analyses coupled with genome-wide in vivo developmental enhancer screens have identified thousands of known and likely regulatory elements in the genome. These have provided the substrate for statistical and experimental identification of regulatory sequences with human-specific developmental activities. On the basis of these early results, the outlines of an integrated strategy have emerged that combines gene expression atlases of human development, in vivo reverse genetic studies of regulatory DNAs, and maps of human-specific sequence change to reveal the genetic basis of unique human biology.

References

Apr 11, 1975·Science·M C King, A C Wilson
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M Moon, T J Ley
Jun 1, 1971·The Quarterly Review of Biology·R J Britten, E H Davidson
Jul 25, 1969·Science·R J Britten, E H Davidson
Apr 25, 2003·Nature·Sean B Carroll
Jun 1, 1961·Journal of Molecular Biology·F JACOB, J MONOD
Jan 1, 1961·Cold Spring Harbor Symposia on Quantitative Biology·J MONOD, F JACOB
Oct 19, 2004·Genome Research·Daniela S GerhardUNKNOWN MGC Project Team
Jul 8, 2005·PLoS Biology·Sean B Carroll
Jul 19, 2005·Genome Research·Adam SiepelDavid Haussler
Sep 2, 2005·Nature·UNKNOWN Chimpanzee Sequencing and Analysis Consortium
Sep 13, 2005·Human Molecular Genetics·Nadav AhituvOlivier Couronne
Nov 9, 2005·PLoS Biology·Matthew V RockmanGregory A Wray
Jun 14, 2006·Genome Research·Shyam PrabhakarLen A Pennacchio
Aug 18, 2006·Nature·Katherine S PollardDavid Haussler
Aug 22, 2006·Nature Reviews. Genetics·Philipp KhaitovichSvante Pääbo
Nov 4, 2006·Science·Shyam PrabhakarEdward M Rubin
Nov 7, 2006·Nature·Len A PennacchioEdward M Rubin
Nov 17, 2006·Nature·Richard E GreenSvante Pääbo
Nov 18, 2006·Science·James P NoonanEdward M Rubin
Dec 13, 2006·Nature Genetics·Sarah A TishkoffPanos Deloukas
Feb 17, 2007·Nature Reviews. Genetics·Gregory A Wray
Apr 10, 2007·Trends in Genetics : TIG·Nicolas Galtier, Laurent Duret
Jan 17, 2008·Genes & Development·Chris J CretekosRichard R Behringer
Feb 5, 2008·Genome Research·Gregory M Cooper, Christopher D Brown
Sep 6, 2008·Science·Shyam PrabhakarJames P Noonan
Sep 13, 2008·Science·Michael D WilsonDuncan T Odom
Feb 7, 2009·Science·Laurent Duret, Nicolas Galtier
Feb 13, 2009·Nature·Axel ViselLen A Pennacchio
Feb 13, 2009·Nature·Tomas Marques-BonetEvan E Eichler
Mar 10, 2009·Genomics·Axel ViselLen A Pennacchio

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Citations

Dec 31, 2015·Molecular Biology and Evolution·Alisha K HollowayKatherine S Pollard
Feb 15, 2014·RNA Biology·Kambiz MousaviVittorio Sartorelli
Feb 8, 2011·Cell·Michael Bulger, Mark Groudine
Oct 15, 2009·Development and Psychopathology·Peter Lafreniere
Jul 1, 2021·Genome Biology·Julius JuddCédric Feschotte

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