PMID: 16638228Apr 28, 2006Paper

Regulatory effects of Bmi-1 gene on self-renewal of hematopoietic stem cells--review

Zhongguo shi yan xue ye xue za zhi
Hui GongWen-Li Liu

Abstract

Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. The Bmi-1 gene is a putative oncogene belonging to the Polycomb group family. Recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal of normal and leukemic stem cells. The research progress on structure and function of Bmi-1 gene, and its role in self-renewal of hematopoietic stem cells was reviewed.

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