PMID: 9435620Jan 22, 1998Paper

Regulatory effects of phospholamban on cardiac function in intact mice

The American Journal of Physiology
John N Lorenz, E G Kranias

Abstract

Phospholamban (PLB) regulates Ca(2+)-adenosinetriphosphatase activity in cardiac sarcoplasmic reticulum and participates in the regulation of myocardial performance. Animal models with altered levels of PLB permit in vivo evaluation of the physiological role of PLB. This study examined left ventricular (LV) performance in intact PLB heterozygous and homozygous mice under basal and stimulated conditions. A Millar Mikro-Tip transducer was inserted into the right carotid artery and advanced into the LV for direct measurement of ventricular pressure and the first derivative of intraventricular pressure (dP/dt). Baseline blood pressures were increased in PLB heterozygotes and even more so in PLB homozygotes compared with wild types (WT), and there were no differences in heart rate or LV end-diastolic pressure. The increase in pressure was primarily caused by an increase in systolic pressure. Baseline values for positive and negative dP/dt were linearly correlated with PLB levels. In PLB heterozygotes, contractile response to isoproterenol (Iso) was blunted compared with WT, but maximum rates of contraction were similar between the two groups. Contractile performance in PLB homozygous mice, which under baseline conditions was similar...Continue Reading

References

May 1, 1996·Circulation Research·W LuoE G Kranias
Jul 1, 1996·The American Journal of Physiology·B M WolskaR J Solaro

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Citations

May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John N Lorenz
Mar 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eiki TakimotoIssei Komuro
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sabine HukeMuthu Periasamy
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·W F BluhmM Meyer
May 18, 2021·EMBO Molecular Medicine·Friederike CuelloArne Hansen
Sep 1, 2021·Nature Communications·Niels Grote BeverborgPeter van der Meer

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