Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses.

Molecular and Cellular Biology
Barbara KroczynskaLeonidas C Platanias

Abstract

The precise mechanisms by which the activation of interferon (IFN) receptors (IFNRs) ultimately controls mRNA translation of specific target genes to induce IFN-dependent biological responses remain ill defined. We provide evidence that IFN-α induces phosphorylation of programmed cell death 4 (PDCD4) protein on Ser67. This IFN-α-dependent phosphorylation is mediated by either the p70 S6 kinase (S6K) or the p90 ribosomal protein S6K (RSK) in a cell-type-specific manner. IFN-dependent phosphorylation of PDCD4 results in downregulation of PDCD4 protein levels as the phosphorylated form of PDCD4 interacts with the ubiquitin ligase β-TRCP (β-transducin repeat-containing protein) and undergoes degradation. This process facilitates IFN-induced eukaryotic translation initiation factor 4A (eIF4A) activity and binding to translation initiation factor eIF4G to promote mRNA translation. Our data establish that PDCD4 degradation ultimately facilitates expression of several ISG protein products that play important roles in the generation of IFN responses, including IFN-stimulated gene 15 (ISG15), p21(WAF1/CIP1), and Schlafen 5 (SLFN5). Moreover, engagement of the RSK/PDCD4 pathway by the type I IFNR is required for the suppressive effects of...Continue Reading

References

Mar 1, 1997·Cytokine & Growth Factor Reviews·D E Levy
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·J L CmarikN H Colburn
Feb 13, 2002·The Journal of Biological Chemistry·Shahab UddinLeonidas C Platanias
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·David E Levy, J E Darnell
May 22, 2003·The Journal of Biological Chemistry·Fatima LekmineLeonidas C Platanias
Nov 19, 2003·Current Opinion in Oncology·Simrit Parmar, Leonidas C Platanias
Mar 31, 2004·Experimental Cell Research·Fatima LekmineLeonidas C Platanias
May 22, 2004·Annals of the New York Academy of Sciences·Rüdiger GökeBrigitte Lankat-Buttgereit
Aug 20, 2004·American Journal of Physiology. Cell Physiology·R GökeB Lankat-Buttgereit
May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Dec 17, 2005·Cancer Research·Alexey PalamarchukYuri Pekarsky
Dec 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Leonidas C Platanias
Nov 23, 2006·The Journal of Biological Chemistry·Surinder KaurLeonidas C Platanias
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja HilliardYouhai H Chen
May 16, 2007·The Journal of Biological Chemistry·Christian SchindlerThomas Decker
Feb 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chikako SuzukiGerhard Wagner
Feb 26, 2008·Cancer Research·Tobias SchmidNancy H Colburn
Mar 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Surinder KaurLeonidas C Platanias
May 27, 2008·Nature Reviews. Cancer·David Frescas, Michele Pagano
Jun 13, 2008·Nature·Brandi N DavisAkiko Hata
Sep 17, 2008·Journal of Cellular and Molecular Medicine·Fei GaoLining Zhang
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Surinder KaurLeonidas C Platanias
Dec 17, 2008·Journal of Hepatology·Andrew W Tai, Raymond T Chung
Feb 13, 2009·The Journal of Biological Chemistry·Amanda J RedigLeonidas C Platanias
Apr 10, 2009·Biology of the Cell·Brigitte Lankat-Buttgereit, Rüdiger Göke
May 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rebecca J Critchley-ThornePeter P Lee
Jul 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sonali JoshiLeonidas C Platanias
Aug 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aibo WangBarbara A Osborne
Aug 18, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Raymond P Donnelly, Sergei V Kotenko
Aug 26, 2010·Science Signaling·Albrecht MoritzMichael J Comb
Nov 16, 2010·The Journal of Biological Chemistry·Barbara KroczynskaLeonidas C Platanias

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Citations

Apr 11, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Evangelos MavrommatisLeonidas C Platanias
Feb 25, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Barbara KroczynskaLeonidas C Platanias
Jul 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Barbara KroczynskaLeonidas C Platanias
Jun 12, 2013·Pest Management Science·Liang GongGuohua Zhong
Jan 2, 2015·Current Opinion in Immunology·Rafael J ArgüelloPhilippe Pierre
Apr 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shuo WangAntonis E Koromilas
Jun 9, 2016·Molecular and Cellular Biology·Jamie L McCallRobert E Lewis
Jun 24, 2017·Cell Death and Differentiation·Holger LingelMonika C Brunner-Weinzierl
Jul 9, 2020·Frontiers in Cellular and Infection Microbiology·Danielle Ahn, Alice Prince
Sep 14, 2014·Molecular Cancer Research : MCR·Eleanor N Fish, Leonidas C Platanias
Dec 12, 2020·Frontiers in Cell and Developmental Biology·Guo PinYu Yanan

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