Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells

The International Journal of Biochemistry & Cell Biology
Ute PanzenboeckWolfgang Sattler

Abstract

The blood-brain barrier contributes to maintain brain cholesterol metabolism and protects this uniquely balanced system from exchange with plasma lipoprotein cholesterol. Brain capillary endothelial cells, representing a physiological barrier to the central nervous system, express apolipoprotein A-I (apoA-I, the major high-density lipoprotein (HDL)-associated apolipoprotein), ATP-binding cassette transporter A1 (ABCA1), and scavenger receptor, class B, type I (SR-BI), proteins that promote cellular cholesterol mobilization. Liver X receptors (LXRs) and peroxisome-proliferator activated receptors (PPARs) are regulators of cholesterol transport, and activation of LXRs and PPARs has potential therapeutic implications for lipid-related neurodegenerative diseases. To clarify the functional impact of LXR/PPAR activation, sterol transport along the: (i) ABCA1/apoA-I and (ii) SR-BI/HDL pathway was investigated in primary, polarized brain capillary endothelial cells, an in vitro model of the blood-brain barrier. Activation of LXR (24(S)OH-cholesterol, TO901317), PPARalpha (bezafibrate, fenofibrate), and PPARgamma (troglitazone, pioglitazone) modulated expression of apoA-I, ABCA1, and SR-BI on mRNA and/or protein levels without compromis...Continue Reading

References

Feb 7, 1997·The Journal of Biological Chemistry·J M LehmannT M Willson
Nov 10, 1998·Circulation·B StaelsJ C Fruchart
Aug 5, 2000·Biochemical and Biophysical Research Communications·K SchwartzD P Wade
Nov 23, 2000·Lancet·H JickD A Drachman
Nov 23, 2000·Genes & Development·J R SchultzB Shan
Nov 30, 2000·Biochemical and Biophysical Research Communications·J SakamotoH Sawada
Mar 27, 2001·Current Opinion in Lipidology·J M Dietschy, S D Turley
Jun 8, 2001·The Journal of Clinical Investigation·G MartinB Staels
Jul 19, 2001·The Journal of Biological Chemistry·T T LuD J Mangelsdorf
Jan 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Hailing LiaoYi Zhu
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ling WangJan-Ake Gustafsson
Dec 10, 2002·Biochemical and Biophysical Research Communications·Lene MalerødTrond Berg
Dec 20, 2002·IUBMB Life·Richard A HawkinsJuan R Viña
Jan 4, 2003·The Journal of Biological Chemistry·Pablo MardonesAttilio Rigotti
Jan 30, 2003·Molecular Endocrinology·Lene K JuvetHilde I Nebb
Mar 27, 2003·Nature Neuroscience·Luigi PuglielliDora M Kovacs
May 20, 2003·The Journal of Biological Chemistry·Yu SunAlan R Tall
May 30, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jin LeeRahul Kuver
Dec 4, 2003·Brain Research. Developmental Brain Research·Gang QuanStephen D Turley
Feb 7, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Ingemar Björkhem, Steve Meaney
Feb 18, 2004·Journal of Lipid Research·Liqing YuHerbert Stangl
May 12, 2004·Current Pharmaceutical Design·David J Begley
Jun 24, 2004·Journal of Neuroscience Research·Steven A SmithSarah J Roberts-Thomson
Jun 24, 2004·Neurobiology of Aging·Allison B ReissMony J de Leon
Jun 26, 2004·The Journal of Pharmacology and Experimental Therapeutics·Yan ZhangDonald W Miller
Aug 5, 2004·Journal of Lipid Research·Elaine M QuinetPonnal Nambi
Oct 20, 2004·Circulation·Brian J O'ConnellJacques Genest

❮ Previous
Next ❯

Citations

Feb 3, 2012·Translational Stroke Research·Adam ChodobskiJoanna Szmydynger-Chodobska
Sep 7, 2011·Nature Reviews. Neurology·Joanna M Karasinska, Michael R Hayden
Dec 4, 2012·Stroke; a Journal of Cerebral Circulation·Xu CuiJieli Chen
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joanna M KarasinskaMichael R Hayden
Apr 23, 2011·Journal of Atherosclerosis and Thrombosis·Álvaro CerdaRosario Dominguez Crespo Hirata
Dec 4, 2009·QJM : Monthly Journal of the Association of Physicians·E Erdmann, R Wilcox
Sep 6, 2011·Biochimica Et Biophysica Acta·Sophie StukasCheryl L Wellington
Jan 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ingrid KratzerWolfgang Sattler
Nov 28, 2013·Biochemical and Biophysical Research Communications·Fabien GosseletLaurence Fenart
Aug 4, 2016·Frontiers in Immunology·Monica de GaetanoOrina Belton
Jul 19, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Hongyan KangXiaoyan Deng
Aug 17, 2019·Frontiers in Immunology·Elien WoutersHelga E de Vries
Jun 25, 2020·International Journal of Molecular Sciences·Li LiXu Cui
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Micaela GliozziVincenzo Mollace
Feb 25, 2020·Experimental Neurology·Eric E Abrahamson, Milos D Ikonomovic
Jun 3, 2021·Antioxidants·Paola GambaGabriella Leonarduzzi

❮ Previous
Next ❯

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