PMID: 18411121Mar 1, 1990Paper

Regulatory elements of the pro-opiomelanocortin gene: pituitary specificity and glucocorticoid repression

Trends in Endocrinology and Metabolism : TEM
J DrouinM Nemer

Abstract

A short 543-bp fragment o f the pro-opiomelanocortin gene is sufficient for pituitary-specific expression and, in the anterior pituitary gland, for repression of pro-opiomelanocortin transcription by glucocorticoids. Within this 5'-flanking fragment of the gene, multiple regulatory elements contribute to tissue-specific expression and a single glucocorticoid receptor binding site acts as a "negative glucocorticoid response element." The current model for glucocorticoid repression depends on the mutually exclusive binding of the glucocorticoid receptor and of a positive transcription factor, the chicken ovalbumin upstream promoter element transcription factor, to overlapping DNA sequences within the negative glucocorticoid response element.

References

Jan 1, 1989·Molecular Endocrinology·Y de KeyzerA Kahn
Jul 1, 1989·Molecular and Cellular Biology·J CharronJ Drouin
Feb 10, 1989·Cell·M Beato
Jun 1, 1986·The Journal of Experimental Medicine·H J WestlyP H Yuen
Nov 25, 1985·FEBS Letters·J DrouinM Nemer
Nov 1, 1987·Molecular and Cellular Biology·L JeannotteJ Drouin
Apr 1, 1985·Molecular and Cellular Endocrinology·J P Gagner, J Drouin
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Jul 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·H Meunier, F Labrie
Jul 1, 1983·Journal of Steroid Biochemistry·L Proulx-FerlandF Labrie

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Citations

May 31, 1993·Annals of the New York Academy of Sciences·F RenéM E Stoeckel
Nov 5, 2004·Médecine sciences : M/S·Anne-Marie PulichinoJacques Drouin
May 31, 1993·Annals of the New York Academy of Sciences·M Therrien, J Drouin
Aug 1, 1993·Clinical Endocrinology·A White, A J Clark
Mar 26, 2003·Genes & Development·Anne-Marie PulichinoJacques Drouin

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