Regulatory forum opinion piece: the role of the toxicologic pathologist in the postgenomic era: challenges and opportunities

Toxicologic Pathology
Robert R Maronpot

Abstract

The "omics," high-throughput screening, computational modeling, and database mining revolutions have each arrived with euphoric expectations, considerable hand waving, and promises to set toxicity testing priorities and reduce reliance on conventional animal toxicity and carcinogenicity testing. Reflecting back on prior experience with other predictive approaches and alternatives, what follows the rush to endorse a promising new technology or different approach to toxicity/carcinogenicity testing is years of grinding out data for validation and optimization. Much of what has driven the enthusiasm for each new emerging technology and approach is the costly, labor-intensive, and sometimes irrelevant and inefficient rodent bioassay-testing paradigm. However, no one should expect abandonment of all animal testing for the foreseeable future, especially for agrochemicals and environmental xenobiotic exposures. It is reasonable to anticipate the future will bring still new approaches to safety testing and human risk assessment. In the past, each new approach has not achieved the inflated expectations for safety testing and human risk assessment but often has become a useful research tool with tangible contributions to basic biology an...Continue Reading

References

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Citations

Oct 17, 2014·Toxicologic Pathology·Jaseer MuhamedThapasimuthu V Anilkumar
Feb 7, 2019·Toxicologic Pathology·Nicole Kirchhof

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