Regulatory immune cells in kidney disease

American Journal of Physiology. Renal Physiology
V W S LeeD C H Harris

Abstract

Lymphocytes and macrophages act as effector immune cells in the initiation and progression of renal injury. Recent data have shown that subpopulations of these immune cells (regulatory T lymphocytes and alternately-activated or regulatory macrophages) are potent modulators of tissue injury and repair in renal disease. Recent animal studies examining the therapeutic effect of these cells raise the exciting possibility that strategies targeting these cell types may be effective in treating and preventing kidney disease in humans. This review will describe their biological role in experimental kidney disease and therapeutic potential in clinical nephrology.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R M Steinman, M D Witmer
Jan 1, 1985·Contributions to Nephrology·G F Schreiner
Mar 1, 1985·Kidney International·P G TippingS R Holdsworth
Sep 1, 1985·Kidney International·F FerrarioG D'Amico
Jul 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J R Diamond
Nov 1, 1993·Kidney International·G G SingerV R Kelley
Jan 15, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R C Atkins
Nov 17, 1998·The Journal of Experimental Medicine·M J PennyB M Hall
Jan 20, 1999·The Journal of Experimental Medicine·H S JunJ W Yoon
Feb 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Kitamura
Feb 7, 1994·Neonatal Intensive Care : the Journal of Perinatology-neonatology·J Brimacombe
Dec 20, 2000·The Journal of Clinical Investigation·T A ChatilaA M Bowcock
Mar 7, 2001·Kidney International·Y WangD C Harris
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D C KluthA J Rees
Aug 3, 2001·The Journal of Biological Chemistry·L A SchubertS F Ziegler
Nov 28, 2001·Immunological Reviews·L ChatenoudJ A Bluestone
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynda M StuartAdam Lacy-Hulbert
May 2, 2002·Clinical and Experimental Immunology·A R KitchingS R Holdsworth
Dec 25, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Heather M WilsonDavid C Kluth
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Feb 18, 2003·The Journal of Clinical Investigation·Nilamadhab MishraGary S Gilkeson
Feb 28, 2003·Clinical and Experimental Immunology·J HeikkinenO Lassila
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell
Mar 5, 2003·Annual Review of Immunology·Ralph M SteinmanMichel C Nussenzweig
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deborah M LendaVicki R Kelley
Mar 27, 2003·Nature Reviews. Immunology·Adrian Hayday, Robert Tigelaar
Mar 27, 2003·Nature Reviews. Immunology·Jeffrey A Bluestone, Abul K Abbas
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Yohei IkezumiDavid J Nikolic-Paterson
Mar 28, 2003·Nature Immunology·Anne O'Garra, Paulo Vieira

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Citations

Dec 24, 2010·Nephrology·Vincent W S Lee, David C H Harris
Oct 31, 2009·Journal of the American Society of Nephrology : JASN·Raghu K Tadagavadi, W Brian Reeves
Nov 10, 2011·Toxins·Ronald P MillerWilliam Brian Reeves
Jan 30, 2016·Journal of Translational Medicine·Peng SunHao Wang
Apr 29, 2011·Kidney International·Hans-Joachim PaustGisa Tiegs
Dec 6, 2008·The Journal of Pathology·C HopkinsM H Little
Oct 25, 2016·Journal of Translational Medicine·Shanzheng LuHao Wang
Apr 12, 2018·PloS One·Jimmy Jianheng ZhouAnne M Durkan
Jul 9, 2013·Journal of the American Society of Nephrology : JASN·Myung-Gyu KimJaeseok Yang
Sep 26, 2020·Scientific Reports·Jun-Gyu ParkSeung Seok Han

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