Nov 13, 2019

Regulatory impairment in untreated Parkinson's disease is not restricted to Tregs: other regulatory populations are also involved

Journal of Neuroinflammation
Diana D Álvarez-LuquínLaura Adalid-Peralta

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Various studies have suggested that the immune response plays a key role in this pathology. While a predominantly pro-inflammatory peripheral immune response has been reported in treated and untreated PD patients, the study of the role of the regulatory immune response has been restricted to regulatory T cells. Other immune suppressive populations have been described recently, but their role in PD is still unknown. This study was designed to analyze the pro and anti-inflammatory immune response in untreated PD patients, with emphasis on the regulatory response. Thirty-two PD untreated patients and 20 healthy individuals were included in this study. Peripheral regulatory cells (CD4+Tregs, Bregs, CD8+Tregs, and tolerogenic dendritic cells), pro-inflammatory cells (Th1, Th2, and Th17 cells; active dendritic cells), and classical, intermediate, and non-classical monocytes were characterized by flow cytometry. Plasmatic levels of TNF-α, IFN-γ, IL-6, GM-CSF, IL-12p70, IL-4, IL-13, IL-17α, IL-1β, IL-10, TGF-β, and IL-35 were determined by ELISA. Decreased levels of suppressor Tregs, active Tregs, Tr1 cells, IL-10-producer CD8regs, and tolerogeni...Continue Reading

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Mentioned in this Paper

Study
Immune Response
Flow Cytometry
Transforming Growth Factor beta
Tumor Necrosis Factor-alpha
Granulocyte Colony-Stimulating Factor
Regulation of Response to Drug
Nerve Degeneration
IL17A
Progesterone

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