Regulatory interplay between pap operons in uropathogenic Escherichia coli

Molecular Microbiology
Makrina TotsikaD L Gally

Abstract

Pathogenic bacteria have a large repertoire of surface organelles involved in adherence, motility and protein export, but how individual bacteria co-ordinate surface organelle expression to prevent interference and excessive immune stimulation is unclear. Phase variation is a mechanism by which expression of surface factors is limited to a fraction of the bacterial population; however, the presence of multiple homologous surface structures controlled by related mechanisms and regulators antagonizes the independent expression achieved by phase variation. To investigate whether other mechanisms have evolved to sort out the bacterial cell surface, we examined regulatory cross-talk between multiple phase-variable pyelonephritis-associated pili (pap) operons in Escherichia coli isolates associated with urinary tract infections. Allelic variation identified in the regulatory regions and regulators acts synergistically to limit coexpression of homologous fimbrial operons. In particular, there is evidence that papI is under positive selection and PapI variants displayed differences in their capacity to activate related pap operons. Alleles of the high-affinity binding site for PapB were shown to contain a variable number of (T/A)(3) re...Continue Reading

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Citations

Mar 9, 2013·Nature Protocols·Sujay ChattopadhyayEvgeni V Sokurenko
Jul 26, 2008·Annual Review of Genetics·Carla J Davidson, Michael G Surette
Feb 6, 2013·PloS One·Daniël J WurpelMark A Schembri
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Feb 24, 2012·Journal of Basic Microbiology·Qiangde DuanGuoqiang Zhu
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Mar 15, 2018·EcoSal Plus·Glenn T Werneburg, David G Thanassi
May 27, 2016·Microbiology Spectrum·Evgeni Sokurenko
Nov 7, 2015·Microbiology Spectrum·Peter Chahales, David G Thanassi

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