PMID: 6974297Jan 1, 1981Paper

Regulatory mechanism of delayed-type hypersensitivity in mice. III. In vitro analysis of memory T cells involved in augmentation of DTH responses

Microbiology and Immunology
S I TamuraY Egashira

Abstract

The memory of delayed-type hypersensitivity (DTH), manifested by the augmented responsiveness upon challenge with alum-absorbed ovalbumin (OA), was induced in mice primed 7 days, 21 days, or 90 days previously with 1 microgram of reduced and alkylated OA. The memory cells involved in the augmentation of DTH responses were analyzed in the in vitro induction system of T cells which mediate DTH against OA. Spleen cells from the primed mice generated DTH-effector T cells (DTH-Te) in a significantly accelerated fashion, compared with unprimed spleen cells, when cultured with OA. The accelerated generation of DTH-Te in vitro was induced antigen specifically and was dependent on a certain T cell population in the primed spleen. The T cell population was found in the spleen of primed mice for at least 3 months after priming, corresponding to the persistence of DTH-memory in vivo. Moreover, it was fractionated in the high-density layer by discontinuous bovine serum albumin gradient centrifugation. The high-density cell population decreased in density with increase in the time of culture and developed into DTH-Te, which were separated in the low-density layer on day 4 of culture. These results indicate that the T cells involved in the ac...Continue Reading

References

Apr 1, 1979·European Journal of Immunology·P A Bretscher
Jun 1, 1975·Journal of Immunological Methods·W F Davidson, C R Parish
Aug 1, 1976·The Journal of Experimental Medicine·R L Whisler, J D Stobo
Feb 1, 1972·Japanese Journal of Medical Science & Biology·T KurataY Watanabe

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