Regulatory Mechanism of MicroRNA Expression in Cancer

International Journal of Molecular Sciences
Zainab Ali SyedaSu Jung Song

Abstract

Altered gene expression is the primary molecular mechanism responsible for the pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are virtually involved at the post-transcriptional level and bind to 3' UTR of their target messenger RNA (mRNA) to suppress expression. Dysfunction of miRNAs disturbs expression of oncogenic or tumor-suppressive target genes, which is implicated in cancer pathogenesis. As such, a large number of miRNAs have been found to be downregulated or upregulated in human cancers and to function as oncomiRs or oncosuppressor miRs. Notably, the molecular mechanism underlying the dysregulation of miRNA expression in cancer has been recently uncovered. The genetic deletion or amplification and epigenetic methylation of miRNA genomic loci and the transcription factor-mediated regulation of primary miRNA often alter the landscape of miRNA expression in cancer. Dysregulation of the multiple processing steps in mature miRNA biogenesis can also cause alterations in miRNA expression in cancer. Detailed knowledge of the regulatory mechanism of miRNAs in cancer is essential for understanding its physiological role and the implications of cancer-associated dysfunction and dysregulation. In this...Continue Reading

References

Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Nov 9, 2004·Nature·Richard I GregoryRamin Shiekhattar
Mar 16, 2005·Cell·Steven M JohnsonFrank J Slack
Jun 10, 2005·Nature·Jun LuTodd R Golub
Jun 10, 2005·Nature·Kathryn A O'DonnellJoshua T Mendell
Sep 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Amelia CimminoCarlo M Croce
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Aug 1, 2006·Nature Genetics·Michael DewsAndrei Thomas-Tikhonenko
Feb 20, 2007·Cancer Research·Amaia LujambioManel Esteller
Jun 8, 2007·Nature·Lin HeGregory J Hannon
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Aleksandra FranovicStephen Lee
Dec 11, 2007·Nature Genetics·Tsung-Cheng ChangJoshua T Mendell
Dec 13, 2007·Nature Reviews. Molecular Cell Biology·Gyorgy Hutvagner, Martin J Simard
Feb 17, 2009·Nature Genetics·Sonia A MeloManel Esteller
Feb 26, 2009·Cell·Andrea Ventura, Tyler Jacks
Jun 27, 2009·Science·D Ashley HillPaul J Goodfellow
Jul 25, 2009·Nature·Hiroshi I SuzukiKohei Miyazono
Apr 14, 2010·International Journal of Molecular Sciences·Hong-Fei XiaXu Ma
Apr 15, 2010·Journal of the National Cancer Institute·Gianpiero Di LevaCarlo M Croce
Jul 8, 2010·Molecular Cell·Shintaro IwasakiYukihide Tomari
Sep 14, 2010·The International Journal of Biochemistry & Cell Biology·George YeohKlaus Kaestner
Sep 30, 2010·Nature Genetics·Pilar GarreMiguel de la Hoya
Oct 23, 2010·Molecular Cell·Anthony K L Leung, Phillip A Sharp
Dec 9, 2010·Cancer Biology & Therapy·Xuan PanRui Wang
Mar 15, 2011·International Journal of Oncology·May Y W WongJia-Lin Yang
Oct 1, 2011·International Journal of Cancer. Journal International Du Cancer·Kuo-Wang TsaiWen-Chang Lin
Dec 23, 2011·The New England Journal of Medicine·Alireza Heravi-MoussaviDavid G Huntsman

❮ Previous
Next ❯

Citations

May 18, 2020·Life·Joanna BoresowiczMateusz Bujko
May 28, 2020·International Journal of Molecular Sciences·Takashi TakeuchiSilvia Zappavigna
Aug 21, 2020·Acta Pharmacologica Sinica·You-Hui YuJian-Tao Ye
Nov 5, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Bing PengXin Li
Jan 7, 2021·Nucleic Acids Research·Paulina Galka-MarciniakPiotr Kozlowski
Dec 18, 2020·Frontiers in Oncology·Tiziana AnneseDomenico Ribatti
Nov 21, 2020·International Journal of Molecular Sciences·Susan Costantini, Alfredo Budillon
Feb 19, 2021·Experimental Dermatology·Roland N WagnerJohann W Bauer
Mar 7, 2021·International Journal of Molecular Sciences·Rebecca RaueBernhard Brüne
Jun 3, 2020·European Journal of Pharmacology·Milad AshrafizadehMasoud Najafi
Jan 14, 2021·Yeungnam University Journal of Medicine·Ji Hoon Jang, Tae-Jin Lee
Apr 1, 2021·Cellular Signalling·Mridul BudakotiManisha Nigam
Apr 9, 2021·Journal of Cellular and Molecular Medicine·Jun-Cheng GuoJin-Fang Zheng
Apr 18, 2021·Stem Cell Research & Therapy·Kai Song, Maryam Farzaneh
Sep 16, 2020·Biochimica Et Biophysica Acta. General Subjects·Angela AvenosoGiuseppe M Campo
Apr 19, 2021·Toxicology and Applied Pharmacology·Yi SunWenchang Zhang
Apr 21, 2021·Seminars in Cell & Developmental Biology·Deepti SinghHifzur R Siddique
May 12, 2021·Disease Models & Mechanisms·Meredith Hill, Nham Tran
May 25, 2021·Computational Biology and Chemistry·Kevin Nathanael RamantoDavid Agustriawan
Jul 3, 2021·Biomolecules·Jacek KabzinskiIreneusz Majsterek
Jun 17, 2021·Molecular Medicine Reports·Qi Zheng, Wei Hou
Jul 25, 2021·International Journal of Molecular Sciences·Tingting ShiTsutomu Masaki
Jul 25, 2021·International Journal of Molecular Sciences·María J PajaresJuan Sandoval
Jul 6, 2021·Parasitology·Sajad RashidiEugenio Antonio Carrera Silva
Aug 12, 2021·Endocrine·Francesca CapriglioneDiego Russo
Aug 18, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zhi Xiong ChongWan Yong Ho

❮ Previous
Next ❯

Methods Mentioned

BETA
immunoprecipitation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Cancer
Shuibin Lin, Richard I Gregory
Journal of Translational Medicine
Lyudmila F Gulyaeva, Nicolay E Kushlinskiy
Methods in Enzymology
George Adrian Calin, Carlo M Croce
Annual Review of Pathology
Yong Sun Lee, Anindya Dutta
© 2021 Meta ULC. All rights reserved