Regulatory mechanisms in postsynaptic phosphorylation networks

Current Opinion in Structural Biology
Marcelo P Coba

Abstract

The modulation of the postsynaptic signaling machinery by protein phosphorylation has attracted much interest since it is key for the understanding of the regulation of a variety of synaptic functions. While advances in mass spectrometry have allowed us to begin performing large-scale analysis of protein phosphorylation in components of the PSD, the systematic collection of datasets and their functional significance within the context of regulatory signaling networks is in its infancy. Here, we will focus on the composition of the PSD phosphoproteome describing kinase, phosphatase, and protein domain modules involved in the regulation of phosphorylation signaling. We will discuss the impact of synaptic plasticity mechanisms such as long-term potentiation (LTP) in mammalian kinomes and describe the general rules of signaling organization in the PSD phosphoproteome.

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Citations

May 29, 2020·The European Journal of Neuroscience·Xavier L WarnetMagnus Kjaergaard
Apr 27, 2021·Biochemical and Biophysical Research Communications·Alexander V Maltsev, Pavel M Balaban
May 4, 2021·Frontiers in Molecular Neuroscience·Erin FingletonKatherine W Roche
Jun 3, 2021·International Journal of Molecular Sciences·Alexander V MaltsevPavel M Balaban
Aug 3, 2021·The Journal of Biological Chemistry·Hai-Long ZhangDong-Min Yin
Aug 7, 2021·The Journal of Biological Chemistry·Hai-Long ZhangDong-Min Yin

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