Regulatory Mechanisms of Inhibitory Immune Checkpoint Receptors Expression

Trends in Cell Biology
Nicolas CurdyDon-Marc Franchini

Abstract

T cells responding to persistent tumor or viral antigens progressively lose their functional properties, a feature known as exhaustion. This state is also characterized by cell-surface expression of multiple inhibitory immune checkpoint receptors (IRs). Cancer immunotherapy by immune checkpoint targeting has shown impressive clinical outcomes, but requires substantial improvement given the limited number of patients who benefit from the treatment. Targeting the mechanisms controlling immune checkpoint expression could represent a step towards this aim. Accumulating data indicate that this strategy can limit immune checkpoint expression, in some instances simultaneously inhibiting several immune checkpoints. This review discusses various mechanisms through which IRs are activated or regulated, and ways these mechanisms could be exploited to develop more effective future immunotherapies.

References

Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia VendettiMaria Teresa De Magistris
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Audrey L KinterAnthony S Fauci
Jan 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seigo TerawakiTasuku Honjo
Jun 2, 2011·Nature Communications·Haik MkhikianMichael Demetriou
Mar 20, 2012·The Journal of Clinical Investigation·Zhi-Zhang YangStephen M Ansell
Oct 2, 2012·American Journal of Respiratory Cell and Molecular Biology·Jinghong LiPatricia W Finn
Oct 17, 2012·Immunology and Cell Biology·Mélissa MathieuNathalie Labrecque
Jan 22, 2013·Nature Immunology·Takashi SekiyaAkihiko Yoshimura
Oct 1, 2013·Nature Immunology·Andrew L DoedensAnanda W Goldrath
Nov 5, 2014·Nature·Yu-Hwa HuangRichard S Blumberg
Jan 21, 2015·The Journal of Experimental Medicine·Thibault VoronMagali Terme
Jan 24, 2015·Nature Communications·Chen ZhuVijay K Kuchroo
Feb 15, 2015·Immunity·Gustavo J MartinezAnjana Rao
Mar 21, 2015·Nature Communications·Han Seok KohEun Jung Park
Jul 5, 2015·Biochemical and Biophysical Research Communications·Elise K HeonOliver A Press
Sep 12, 2015·Cell·Sonja KleffelTobias Schatton
Dec 9, 2015·Trends in Cancer·Anand S Bhagwat, Christopher R Vakoc
Dec 15, 2015·Neuro-oncology·Jun WeiAmy B Heimberger
Feb 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gustavo J MartinezAnjana Rao
Mar 6, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander P R BallyJeremy M Boss
Apr 29, 2016·Nature Reviews. Immunology·Arnav Mehta, David Baltimore
May 19, 2016·Immunity·Qianxia Zhang, Dario A A Vignali
Jun 10, 2016·Nature·Keisuke KataokaSeishi Ogawa
Jun 25, 2016·British Journal of Biomedical Science·Haniyeh FooladinezhadAbbas Doosti
Jul 20, 2016·The New England Journal of Medicine·Jesse M ZaretskyAntoni Ribas
Aug 3, 2016·The Journal of Experimental Medicine·SuJin HwangImtiaz A Khan
Sep 7, 2016·The Journal of Clinical Investigation·Gavin M LewisElina I Zuniga
Sep 30, 2016·Cancer Discovery·Benjamin V ParkAndrea L Cox
Oct 30, 2016·Science·Debattama R SenW Nicholas Haining
Dec 3, 2016·Cancer Discovery·Daniel Sanghoon ShinAntoni Ribas
Jan 19, 2017·Immunity·Tom L StephenJose R Conejo-Garcia

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Citations

May 10, 2020·International Journal of Cancer. Journal International Du Cancer·Daniele CaraccioloPierfrancesco Tassone
Jan 18, 2020·Oxidative Medicine and Cellular Longevity·Andra Diana AndreicuțAlexandru Irimie
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martina GoracciSerena Marchiò
Dec 2, 2020·Cell Death & Disease·Michael FichtnerJochen H M Prehn
Dec 22, 2020·Frontiers in Neuroscience·Antonio MunafòGiuseppina Cantarella
Jan 1, 2021·Cancers·Allison A FitzgeraldLouis M Weiner
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Nicolas CurdyDon-Marc Franchini
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Chengyi MaoYong Yuan
Jun 3, 2021·Biomedicines·Isaac G OnyangoGorazd B Stokin
Jul 9, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Roshal R PatelJames W Welsh

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