PMID: 12757861May 22, 2003Paper

Regulatory modules in the developing heart

Cardiovascular Research
Petra E M H HabetsV M Christoffels

Abstract

Fragments of regulatory DNA of cardiac genes drive reporter gene expression in sometimes unexpected subdomains of the heart. These patterns have revealed that the regulatory DNA of genes consists of distinct subfragments (regulatory modules) that are active in different regions of the developing heart. In this review we give an overview of the activity of regulatory modules in vivo. Furthermore, we investigated the relationship between the activity domains of the regulatory modules, the building blocks of the heart and the developmental patterning of the myocardium. Most of the regulatory modules show a domain of activity broader than the morphological boundary of a cardiac compartment and seem to respond to a patterning program along the antero-posterior axis.

Citations

Mar 24, 2007·Cellular and Molecular Life Sciences : CMLS·W M H HoogaarsV M Christoffels
Nov 24, 2005·Nature Reviews. Genetics·Margaret BuckinghamStéphane Zaffran
Aug 3, 2011·Canadian Journal of Physiology and Pharmacology·Benoit G Bruneau
May 14, 2011·Cardiovascular Research·Alex V PostmaConnie R Bezzina
Jun 18, 2004·Annals of the New York Academy of Sciences·Antoon F M MoormanVincent M Christoffels
Oct 28, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Shannon M HarlanJim Jung-Ching Lin
Feb 17, 2007·Annals of the New York Academy of Sciences·Bradley B KellerKimimasa Tobita
Jan 10, 2013·Acta Physiologica·M S RanaA F M Moorman
Dec 15, 2004·Trends in Cardiovascular Medicine·Vincent M ChristoffelsAntoon F M Moorman
Aug 5, 2006·International Journal of Cardiology·Yisong ZhenRutai Hui
Oct 27, 2006·Developmental Biology·Matthias StadtfeldThomas Graf
May 18, 2012·Reproductive Sciences·Monique W M de LaatCarrie Ris-Stalpers
Mar 26, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Vincent M ChristoffelsMarina Campione

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