Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates

The Journal of Nutritional Biochemistry
Wenjuan Shi JobgenGuoyao Wu

Abstract

Nitric oxide (NO) is synthesized from L-arginine by NO synthase in virtually all cell types. Emerging evidence shows that NO regulates the metabolism of glucose, fatty acids and amino acids in mammals. As an oxidant, pathological levels of NO inhibit nearly all enzyme-catalyzed reactions through protein oxidation. However, as a signaling molecule, physiological levels of NO stimulate glucose uptake as well as glucose and fatty acid oxidation in skeletal muscle, heart, liver and adipose tissue; inhibit the synthesis of glucose, glycogen, and fat in target tissues (e.g., liver and adipose); and enhance lipolysis in adipocytes. Thus, an inhibition of NO synthesis causes hyperlipidemia and fat accretion in rats, whereas dietary arginine supplementation reduces fat mass in diabetic fatty rats. The putative underlying mechanisms may involve multiple cyclic guanosine-3',5'-monophosphate-dependent pathways. First, NO stimulates the phosphorylation of adenosine-3',5'-monophosphate-activated protein kinase, resulting in (1) a decreased level of malonyl-CoA via inhibition of acetyl-CoA carboxylase and activation of malonyl-CoA decarboxylase and (2) a decreased expression of genes related to lipogenesis and gluconeogenesis (glycerol-3-phos...Continue Reading

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D L Vesely
Nov 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R J Barnard, J F Youngren
Apr 1, 1992·Physiological Reviews·R L JungasJ T Brosnan
May 1, 1992·The Journal of Clinical Investigation·B B Kahn
Apr 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R D CurranT R Billiar
Sep 1, 1985·The American Journal of Physiology·R NesherD M Kipnis
May 1, 1974·Journal of Animal Science·H J Mersmann
Dec 8, 1994·Nature·L KobzikJ S Stamler
Jun 15, 1995·Biochemical and Biophysical Research Communications·L KobzikJ S Stamler
Apr 2, 1994·Lancet·A MatsumotoT Serizawa
May 1, 1994·The Biochemical Journal·R A HortonM A Titheradge
Dec 26, 1995·Biochemical and Biophysical Research Communications·M KojimaK Kangawa
Jan 5, 1996·Biochemical and Biophysical Research Communications·T E BatesJ B Clark
May 24, 1996·Biochemical and Biophysical Research Communications·C RibiereY Giudicelli
Oct 3, 1996·Biochemical and Biophysical Research Communications·U FrandsenY Hellsten
Dec 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I GathU Förstermann
Jan 1, 1997·Journal of Applied Physiology·T W Balon, J L Nadler
Jan 15, 1998·FEBS Letters·P Ghafourifar, C Richter
Apr 18, 1998·The Biochemical Journal·F SprangersA J Meijer
Jun 6, 1998·The Journal of Biological Chemistry·A Tatoyan, C Giulivi
Jun 5, 1998·The Journal of Biological Chemistry·N GaudiotC Ribière
Jun 24, 1998·Biochimica Et Biophysica Acta·E M Kurowska, K K Carroll
Jun 24, 1998·International Journal of Immunopharmacology·H FarghaliK Masek
Aug 4, 1998·The Journal of Nutrition·G Wu
Nov 10, 1998·The Biochemical Journal·G Wu, S M Morris
May 13, 1999·Biochimica Et Biophysica Acta·J W Denninger, M A Marletta
Jun 11, 1999·Bioscience, Biotechnology, and Biochemistry·A KhedaraN Kato
Aug 17, 1999·Annual Review of Nutrition·B B Rasmussen, R R Wolfe
Jan 26, 2000·Metabolism: Clinical and Experimental·L D MontiP M Piatti
Oct 13, 2000·American Journal of Physiology. Cell Physiology·N GaudiotY Giudicelli
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·Z P ChenB E Kemp
Oct 29, 2000·The Journal of Nutrition·G Wu, C J Meininger

❮ Previous
Next ❯

Citations

May 26, 2010·European Journal of Applied Physiology·Antoni SuredaAntoni Pons
Dec 22, 2009·Pflügers Archiv : European journal of physiology·Yuansheng Gao
Aug 2, 2008·Amino Acids·W W WangD F Li
Nov 26, 2008·Amino Acids·Guoyao WuYulong Yin
Jan 9, 2009·Amino Acids·J Marc Rhoads, Guoyao Wu
Mar 7, 2009·Amino Acids·Xilong LiGuoyao Wu
Mar 21, 2009·Amino Acids·Guoyao Wu
Sep 16, 2010·Amino Acids·Xilong LiGuoyao Wu
Apr 4, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bruce H Cohen
Apr 9, 2008·The British Journal of Nutrition·François MariottiJean François Huneau
Jan 28, 2010·The British Journal of Nutrition·Fugui YinYulong Yin
Mar 12, 2013·Animal : an International Journal of Animal Bioscience·A M FouadJ H Yao
May 28, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K DavisonP R C Howe
Apr 8, 2011·Antioxidants & Redox Signaling·David L KatzAther Ali
Nov 3, 2011·Antioxidants & Redox Signaling·Junjun WangGuoyao Wu
Jan 15, 2013·Antioxidants & Redox Signaling·Michele UmbrelloMervyn Singer
Jul 1, 2011·Genes & Development·Lucía CáceresHenry M Krause
Oct 31, 2012·BMC Cell Biology·April K MarroneHalyna R Shcherbata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.